Sokolova I B, Sergeev I V, Ryzhak G A, Khavinson V Kh
I.P.Pavlov Institute of Physiology, RAS, Saint-Petersburg, 199034, Russian Federation;
Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation.
Adv Gerontol. 2016;29(2):291-296.
Using a TV device to study brain microcirculation, we found that after a course of vascular peptide bioregulator the density of microvascular network of pia matter of old rats (22-24 months) sensomotor cortex increased about 2,5-2,8 times compared to control old rates; and noradrenaline-induced constriction reactions and acetylcholine-induced dilative reactions of the pial arterioles increased significantly. This perfusion in the tissue of the cerebral cortex is not increased, but the degree of blood oxygen saturation in the microvasculature of this tissue region raised.
通过使用电视设备研究脑微循环，我们发现，在给予一个疗程的血管肽生物调节剂后，老年大鼠（22 - 24个月）感觉运动皮层软脑膜的微血管网络密度相比对照老年大鼠增加了约2.5 - 2.8倍；软脑膜小动脉的去甲肾上腺素诱导的收缩反应和乙酰胆碱诱导的舒张反应也显著增强。大脑皮层组织中的灌注并未增加，但该组织区域微血管中的血氧饱和度程度提高了。
