Sokolova I B, Sergeev I V, Fedotova O R, Dvoretskiĭ D P
Adv Gerontol. 2013;26(3):437-41.
We studied the density of whole microvascular network and separately the density of arterioles in the pia mater of sensorimotor cortex of rats of different ages. Also pial arteriolar reactivity on exposure to norepinephrine or acetylcholine chloride was evaluated. The microvascular density and the arteriolar reactivity in the pia mater were not significantly changed before the age of 12 months. In the age of 22-24 months the density of whole microvascular network decreased 1,7 times at the mean and the density of arterioles decreased 1,2 times. There were no significant changes of pia arterioles constriction during the animals life but dilatation was noticeably worse in senility. Orientation and exploratory behavior got worse to the age of 22-24 months: the number of behavioral acts in the "open field" test decreased 1,5-2,3 times in comparison with young animals.
我们研究了不同年龄大鼠感觉运动皮层软膜中整个微血管网络的密度，并分别研究了小动脉的密度。此外，还评估了软膜小动脉对去甲肾上腺素或氯化乙酰胆碱暴露的反应性。在12个月龄之前，软膜中的微血管密度和小动脉反应性没有显著变化。在22 - 24个月龄时，整个微血管网络的密度平均下降了1.7倍，小动脉的密度下降了1.2倍。在动物的生命过程中，软膜小动脉的收缩没有显著变化，但在衰老过程中扩张明显变差。到22 - 24个月龄时，定向和探索行为变差：与年轻动物相比，“旷场”试验中的行为动作数量减少了1.5 - 2.3倍。
