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Valproic Acid for a Treatment of Retinitis Pigmentosa: Reasons for Optimism and Caution.

作者信息

Todd Levi, Zelinka Christopher

机构信息

Department of Neuroscience, College of Medicine, Ohio State University, Columbus, Ohio 43210, and

Department of Biological Science, Florida State University, Tallahassee, Florida 32306.

出版信息

J Neurosci. 2017 May 24;37(21):5215-5217. doi: 10.1523/JNEUROSCI.0774-17.2017.

DOI:10.1523/JNEUROSCI.0774-17.2017
PMID:28539347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5456104/
Abstract
摘要

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本文引用的文献

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Opposing Effects of Valproic Acid Treatment Mediated by Histone Deacetylase Inhibitor Activity in Four Transgenic Models of Retinitis Pigmentosa.丙戊酸治疗在四种视网膜色素变性转基因模型中通过组蛋白去乙酰化酶抑制剂活性介导的相反作用。
J Neurosci. 2017 Jan 25;37(4):1039-1054. doi: 10.1523/JNEUROSCI.1647-16.2016.
2
Autophagy supports survival and phototransduction protein levels in rod photoreceptors.自噬维持视杆光感受器的存活及光转导蛋白水平。
Cell Death Differ. 2015 Mar;22(3):488-98. doi: 10.1038/cdd.2014.229. Epub 2015 Jan 9.
3
Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice.丙戊酸对Rd1和Rd10视网膜变性小鼠光感受器丧失的不同影响。
Mol Vis. 2014 Nov 4;20:1527-44. eCollection 2014.
4
High prevalence of PRPH2 in autosomal dominant retinitis pigmentosa in france and characterization of biochemical and clinical features.法国常染色体显性遗传视网膜色素变性中 PRPH2 的高患病率及生化和临床特征的描述。
Am J Ophthalmol. 2015 Feb;159(2):302-14. doi: 10.1016/j.ajo.2014.10.033. Epub 2014 Nov 5.
5
Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosa.在非洲爪蟾视网膜色素变性转基因模型中，光激活诱导视杆外段视紫红质突变体T4K和T17M的不稳定性是视网膜变性的基础。
J Neurosci. 2014 Oct 1;34(40):13336-48. doi: 10.1523/JNEUROSCI.1655-14.2014.
6
Retinal implants: a systematic review.视网膜植入物：系统评价。
Br J Ophthalmol. 2014 Jul;98(7):852-6. doi: 10.1136/bjophthalmol-2013-303708.
7
Vitamin A and fish oils for retinitis pigmentosa.维生素A和鱼油用于治疗视网膜色素变性。
Cochrane Database Syst Rev. 2013 Dec 19;2013(12):CD008428. doi: 10.1002/14651858.CD008428.pub2.
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Genes and mutations causing retinitis pigmentosa.导致视网膜色素变性的基因和突变。
Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
9
Valproate promotes survival of retinal ganglion cells in a rat model of optic nerve crush.丙戊酸盐促进视神经钳夹大鼠模型中视网膜神经节细胞的存活。
Neuroscience. 2012 Nov 8;224:282-93. doi: 10.1016/j.neuroscience.2012.07.056. Epub 2012 Aug 4.
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