奈多罗米对人体皮肤风团反应的影响。
The effect of nedocromil on weal reactions in human skin.
作者信息
Humphreys F, Shuster S
机构信息
Department of Dermatology, University of Newcastle upon Tyne.
出版信息
Br J Clin Pharmacol. 1987 Oct;24(4):405-8. doi: 10.1111/j.1365-2125.1987.tb03191.x.
Abstract
- Nedocromil 2% iontophoresed into human skin had no effect on wealing produced by intradermal histamine, 48/80 or house dust mite antigen. 2. Iontophoresis of 0.002-2% nedocromil itself resulted in dose-related wealing. 3. This wealing was reduced by 62 +/- 8% s.e. mean by the H1-receptor antagonist terfenadine which decreased histamine wealing by 68 +/- 2% s.e. mean. 4. Nedocromil may therefore act as a weak agonist on a skin mast cell receptor concerned with histamine release.
摘要
- 将2%的奈多罗米经离子导入人体皮肤后，对皮内注射组胺、48/80或屋尘螨抗原所产生的风团没有影响。2. 0.002 - 2%的奈多罗米本身进行离子导入会导致与剂量相关的风团。3. H1受体拮抗剂特非那定使这种风团减少了62±8%（标准误均值），而特非那定使组胺所致风团减少了68±2%（标准误均值）。4. 因此，奈多罗米可能作为一种弱激动剂作用于与组胺释放有关的皮肤肥大细胞受体。
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