Park Jong Suk, Rehman Shaheed Ur, Kim In Sook, Choi Min Sun, Na Chun-Soo, Yoo Hye Hyun
Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of Korea.
Lifetree Biotech Co., Ltd., Suwon, Gyeonggi-do, Republic of Korea.
Pharmacogn Mag. 2017 Apr-Jun;13(50):236-239. doi: 10.4103/0973-1296.204552. Epub 2017 Apr 18.
(Rhamnaceae) fruits are popularly used as herbal medicines or dietary supplements in Asian countries due to functions such as liver protection and detoxification from alcohol poisoning. Accordingly, it is very likely for dietary supplemental products, including fruit extracts, to be taken with prescription drugs.
In this study, possible food-drug interactions involving fruit extracts were evaluated based on the inhibition of cytochrome P450 (CYP) enzyme activity.
The water extract of fruit extracts was incubated in human liver microsomes with CYP-specific substrates. The formation of the CYP-specific metabolites was measured using liquid chromatography-tandem mass spectrometry.
fruit extracts showed negligible effects on seven CYP isozyme activities at all concentrations tested.
This result suggests that fruit extracts may have minimal pharmacokinetic interactions with coadministered drugs through the modulation of CYP enzymes.
Food-drug interactions involving fruit extracts were evaluated.The inhibition of CYPs by extracts was tested. extracts showed negligible effects on CYP activities. extracts may have minimal pharmacokinetic interactions with co-administered drugs. CYP: cytochrome P450 enzymes, HPLC: High performance liquid chromatography, LC-MS/MS : liquid chromatography-tandem mass spectrometry, MRM: multiple-reaction monitoring.
鼠李科果实由于具有肝脏保护和酒精中毒解毒等功能，在亚洲国家被广泛用作草药或膳食补充剂。因此，包括果实提取物在内的膳食补充产品很可能与处方药一起服用。
在本研究中，基于细胞色素P450（CYP）酶活性的抑制作用，评估了涉及果实提取物的可能的食物-药物相互作用。
果实提取物的水提取物与人肝微粒体及CYP特异性底物一起孵育。使用液相色谱-串联质谱法测量CYP特异性代谢产物的形成。
在所有测试浓度下，果实提取物对七种CYP同工酶活性的影响可忽略不计。
该结果表明，果实提取物通过调节CYP酶，可能与共同给药的药物发生最小的药代动力学相互作用。
评估了涉及果实提取物的食物-药物相互作用。测试了提取物对CYPs的抑制作用。提取物对CYP活性的影响可忽略不计。提取物可能与共同给药的药物发生最小的药代动力学相互作用。CYP：细胞色素P450酶，HPLC：高效液相色谱，LC-MS/MS：液相色谱-串联质谱，MRM：多反应监测。
