Effect of L. and Extracts on Antibiotic-resistant Bacteria.

BACKGROUND

The chemical composition of plants used in traditional medicine exhibits biologically active compounds, such as tannins, flavonoids, and alkaloids and becomes a promising approach to treat microbial infections, mainly with drug-resistant bacteria.

OBJECTIVE

The aim of the present study was to evaluate the hydroethanolic leaf extracts of () and () as antimicrobial potential against clinical isolated and Methicillin-resistant .

MATERIALS AND METHODS

Hydroethanolic leaf extracts were prepared and characterized by high-performance liquid chromatography/diode array detection, Fourier transform infrared, 1,1-diphenyl-2-picrylhydrazyl, and ultraviolet-visible methods. The antimicrobial activity against four strains of clinical relevance was evaluated by the microdilution method at minimum inhibitory concentrations.

RESULTS

Phenolic compounds such as flavonoids were detected in the plant extracts. extract at 500 μg/mL showed antimicrobial activity against and ; however, showed only activity against in this concentration.

CONCLUSIONS

Our results suggested that polyphenols and flavonoids present in leaf extracts are a potential source of antimicrobial compound. The extract showed antibacterial activity against and while had effect only on meropenem resistant.

SUMMARY

Antibacterial effect of and leaf extract was evaluated. extract displayed activity against and strains. showed effect on meropenem resistant. BHI: Agar brain heart infusion, CAPES: Coordination for the improvement of higher education personnel, DPPH: 1,1-diphenyl-2-picrylhydrazyl, FAPITEC/SE: Foundation for support to research and technological innovation of the state of sergipe, FTIR: Fourier transform infrared spectroscopy, HPLC: High-performance liquid chromatography, KBr: Potassium bromide, MIC: Minimum inhibitory concentration, MRSA: Methicillin-resistant , RSC: Radical scavenging capacity, UV-vis: Ultraviolet-visible.