Rothman Adam L, Mangalesh Shwetha, Chen Xi, Toth Cynthia A
Department of Ophthalmology, Duke University School of Medicine, Durham.
Department of Internal Medicine, Cone Health, Greensboro.
Eye Brain. 2016 May 27;8:123-133. doi: 10.2147/EB.S97660. eCollection 2016.
Preterm infants with retinopathy of prematurity are at increased risk of poor neurodevelopmental outcomes. Because the neurosensory retina is an extension of the central nervous system, anatomic abnormalities in the anterior visual pathway often relate to system and central nervous system health. We describe optical coherence tomography as a powerful imaging modality that has recently been adapted to the infant population and provides noninvasive, high-resolution, cross-sectional imaging of the infant eye at the bedside. Optical coherence tomography has increased understanding of normal eye development and has identified several potential biomarkers of brain abnormalities and poorer neurodevelopment.
患有早产儿视网膜病变的早产儿出现神经发育不良结局的风险增加。由于神经感觉视网膜是中枢神经系统的延伸，前视觉通路的解剖学异常通常与全身及中枢神经系统健康相关。我们将光学相干断层扫描描述为一种强大的成像方式，该技术最近已适用于婴儿群体，并可在床边对婴儿眼睛进行非侵入性、高分辨率的横断面成像。光学相干断层扫描加深了我们对正常眼睛发育的理解，并已识别出几种脑异常和较差神经发育的潜在生物标志物。
