Geier David A, King Paul G, Hooker Brian S, Dórea José G, Kern Janet K, Sykes Lisa K, Geier Mark R
Institute of Chronic Illnesses, Inc., 14 Redgate Ct., Silver Spring, MD 20905, USA.
CoMeD, Inc., 14 Redgate Ct., Silver Spring, MD 20905, USA.
Clin Chim Acta. 2015 Apr 15;444:212-20. doi: 10.1016/j.cca.2015.02.030. Epub 2015 Feb 21.
Thimerosal (or Thiomersal) is a trade name for an organomercurial compound (sodium ethyl-mercury (Hg) thiosalicylate) that is 49.55% Hg by weight, which rapidly decomposes in aqueous saline solutions into ethyl-Hg hydroxide and ethyl-Hg chloride. Developed in 1927, it has been and is still being used as a preservative in some cosmetics, topical pharmaceuticals, and biological drug products, including vaccines. Concerns have been voiced about its use because it is toxic to human cells. Although it is banned in several countries, it continues to be added to some vaccines in the United States and many vaccines in the developing world.
This critical review focuses on the clinical, epidemiological, and biochemical studies of adverse effects from Thimerosal in developing humans. This review will include research that examines fetal, infant, and childhood death; birth defects; neurodevelopmental testing deficits in children; and neurodevelopmental disorders (attention deficit/hyperactivity disorder, autism spectrum disorder, tic disorder, and specific developmental delays). The review will also look at the research that examined the outcomes of acute accidental ethyl-Hg poisoning in humans. The studies that examine the underlying biochemical insights into the neuronal cellular damage will also be explored.
The culmination of the research that examines the effects of Thimerosal in humans indicates that it is a poison at minute levels with a plethora of deleterious consequences, even at the levels currently administered in vaccines.
硫柳汞（或硫柳汞）是一种有机汞化合物（乙基汞硫代水杨酸钠）的商品名，其汞含量按重量计为49.55%，在盐水溶液中会迅速分解为氢氧化乙基汞和氯化乙基汞。它于1927年研制出来，过去和现在都被用作某些化妆品、外用药品和生物药品（包括疫苗）中的防腐剂。由于它对人体细胞有毒，人们对其使用表示担忧。尽管在几个国家已被禁用，但在美国仍继续被添加到一些疫苗中，在发展中国家许多疫苗中也仍在使用。
这篇批判性综述聚焦于硫柳汞对发育中的人类产生不良反应的临床、流行病学和生化研究。该综述将包括对胎儿、婴儿和儿童死亡；出生缺陷；儿童神经发育测试缺陷；以及神经发育障碍（注意力缺陷多动障碍、自闭症谱系障碍、抽动障碍和特定发育迟缓）的研究。该综述还将审视关于人类急性意外乙基汞中毒后果的研究。对神经元细胞损伤潜在生化见解的研究也将被探讨。
对硫柳汞对人类影响的研究结果表明，即使在疫苗目前使用的剂量水平下，它也是一种微量毒药，会带来诸多有害后果。
