Kojima Shuji, Tsukimoto Mitsutoshi, Shimura Noriko, Koga Hironobu, Murata Akishisa, Takara Tsuyoshi
Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS), Noda-Shi, Chiba, Japan.
Faculty of Pharmaceutical Sciences, Ohu University, Koriyama, Japan.
Dose Response. 2017 Mar 23;15(1):1559325817697531. doi: 10.1177/1559325817697531. eCollection 2017 Jan-Mar.
There is considerable evidence from experimental studies in animals, as well as from clinical reports, that low-dose radiation hormesis is effective for the treatment of cancer and ulcerative colitis. In this study, we present 3 case reports that support the clinical efficacy of low-dose radiation hormesis in patients with these diseases. First, a patient with prostate cancer who had undergone surgical resection showed a subsequent increase in prostate-specific antigen (PSA). His PSA value started decreasing immediately after the start of repeated low-dose X-ray irradiation treatment and remained low thereafter. Second, a patient with prostate cancer with bone metastasis was treated with repeated low-dose X-ray irradiation. His PSA level decreased to nearly normal within 3 months after starting the treatment and remained at the low level after the end of hormesis treatment. His bone metastasis almost completely disappeared. Third, a patient with ulcerative colitis showed a slow initial response to repeated low-dose irradiation treatment using various modalities, including drinking radon-containing water, but within 8 months, his swelling and bleeding had completely disappeared. After 1 year, the number of bowel movements had become normal. Interest in the use of radiation hormesis in clinical practice is increasing, and we hope that these case reports will encourage further clinical investigations.
来自动物实验研究以及临床报告的大量证据表明，低剂量辐射兴奋效应对于癌症和溃疡性结肠炎的治疗是有效的。在本研究中，我们呈现3例病例报告，这些报告支持低剂量辐射兴奋效应在患有这些疾病的患者中的临床疗效。首先，一名接受过手术切除的前列腺癌患者，其前列腺特异性抗原（PSA）随后出现升高。在开始重复低剂量X射线照射治疗后不久，他的PSA值立即开始下降，此后一直保持在较低水平。其次，一名患有骨转移的前列腺癌患者接受了重复低剂量X射线照射治疗。在开始治疗后的3个月内，他的PSA水平降至几乎正常，并在兴奋效应治疗结束后一直保持在低水平。他的骨转移几乎完全消失。第三，一名溃疡性结肠炎患者对包括饮用含氡水在内的各种方式的重复低剂量照射治疗最初反应缓慢，但在8个月内，他的肿胀和出血完全消失。1年后，排便次数恢复正常。临床实践中对辐射兴奋效应应用的兴趣正在增加，我们希望这些病例报告将鼓励进一步的临床研究。
