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狭窄股动脉中的壁面剪应力和近壁血流。

Wall shear stress and near-wall flows in the stenosed femoral artery.

作者信息

Barber T

机构信息

a School of Mechanical & Manufacturing Engineering , University of New South Wales , Sydney , Australia .

出版信息

Comput Methods Biomech Biomed Engin. 2017 Aug;20(10):1048-1055. doi: 10.1080/10255842.2017.1331342. Epub 2017 May 25.

Abstract

Stenotic artery hemodynamics are often characertised by metrics including oscillatory shear index (OSI) and residence time (RT). This analysis was conducted to clarify the link between the near-wall flow behaviour and these resultant flow metrics. A computational simulation was conducted of a stenosed femoral artery, with an idealised representative geometry and a physiologically realistic inlet profile. The overall flow behaviour was characterised through consideration of the axial flow, which was non-dimensionalised against mean flow velocity. The OSI and RT metrics, which are a useful indicator of likely atherosclerotic sites, were explained through a discussion of the WSS values at different time points, the velocity behaviour and velocity profiles, with a particular focus on the near-wall behaviour which influences wall shear stress and the transient evolution of the wall shear stress. While, the stenosis throat experiences high values of wall shear stress, the smooth flow through this contracted region results in low variation in wall shear stress vectors and limited opportunity for any particle stasis. However, regions were noted distal and proximal (though to a lesser extent), where the change in recirculation zones over the cycle created highly elevated regions of both OSI and RT.

摘要

狭窄动脉的血流动力学通常由包括振荡剪切指数(OSI)和停留时间(RT)等指标来表征。进行这项分析是为了阐明近壁血流行为与这些所得血流指标之间的联系。对一条狭窄的股动脉进行了计算模拟,采用理想化的代表性几何形状和生理现实的入口轮廓。通过考虑轴向血流来表征整体血流行为,轴向血流相对于平均流速进行了无量纲化。通过讨论不同时间点的壁面切应力(WSS)值、速度行为和速度剖面,特别是关注影响壁面切应力和壁面切应力瞬态演变的近壁行为,解释了作为可能的动脉粥样硬化部位有用指标的OSI和RT指标。虽然狭窄喉部经历高壁面切应力值,但通过该收缩区域的平稳血流导致壁面切应力矢量变化较小,且颗粒停滞的机会有限。然而,在狭窄部位的远侧和近侧(尽管程度较小)区域被注意到,在这些区域,循环区域在一个周期内的变化产生了OSI和RT都高度升高的区域。

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