Sancho M J, Gomez-Muñoz A, Sanchez-Bueno A, Trueba M, Marino A
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad del País Vasco, Bilbao/Spain.
Exp Clin Endocrinol. 1988 Dec;92(2):154-60. doi: 10.1055/s-0029-1210795.
Glycogen phosphorylase activity is increased before protein synthesis activation by progesterone. This effect is not blocked by antibiotics (actinomycin D and cycloheximide) that are known to inhibit mRNA or protein synthesis. At times similar to those of phosphorylase activation, cAMP are not enhanced, as would be expected considering the classical glycogenolytic cascade, but depleted with respect to control values. A little earlier, cGMP levels are significantly increased.
在孕酮激活蛋白质合成之前，糖原磷酸化酶活性增加。这种效应不会被已知抑制mRNA或蛋白质合成的抗生素（放线菌素D和环己酰亚胺）所阻断。在与磷酸化酶激活相似的时间点，cAMP并未如经典糖原分解级联反应所预期的那样增加，而是相对于对照值减少。稍早一些时候，cGMP水平显著升高。
