Diez A, Sancho M J, Egaña M, Trueba M, Marino A, Macarulla J M
Horm Metab Res. 1984 Sep;16(9):475-7. doi: 10.1055/s-2007-1014823.
The existence of an early effect of testosterone, prior to the effects dependent upon interaction between the hormone-citosolic receptor complex and the cellular nucleus, has been explored in the present paper, in 3-day old chickens. Liver glycogen phosphorylase activity is increased before protein synthesis activation, and furthermore this effect is not blocked by antibiotics (actinomicin D and cycloheximide) inhibitor of protein synthesis. When liver phosphorylase is activated, cAMP levels are not enhanced, as would be expected, but deeply depleted. The hypothesis of a phosphorylase-kinase activation due to an increase in the intracellular Ca++ concentration is considered.
本文在3日龄雏鸡中探讨了睾酮早期效应的存在，该效应先于依赖激素 - 胞质受体复合物与细胞核相互作用的效应。肝糖原磷酸化酶活性在蛋白质合成激活之前就增加了，而且这种效应不会被蛋白质合成抑制剂抗生素（放线菌素D和环己酰亚胺）阻断。当肝磷酸化酶被激活时，cAMP水平并未如预期那样升高，而是大幅降低。考虑了由于细胞内Ca++浓度增加导致磷酸化酶激酶激活的假说。
