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2
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A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors.一种与膜相关的孕酮结合蛋白，即25-Dx，在参与雌性生殖行为的脑区中受孕酮调节。
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Rapid non-genomic activation of cytosolic cyclic AMP-dependent protein kinase activity and [Ca(2+)](i) by 17beta-oestradiol in female rat distal colon.17β-雌二醇对雌性大鼠远端结肠胞质环磷酸腺苷依赖性蛋白激酶活性和[Ca(2+)]i的快速非基因组激活
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6
Covalent modification of proteins by ligands of steroid hormone receptors.类固醇激素受体配体对蛋白质的共价修饰。
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本文引用的文献

1
Uptake in vivo of 45Ca in male accessory sex organs of the rat: effect of estramustine phosphate and diethylstilbestrol diphosphate.大鼠雄性附属性器官对45Ca的体内摄取：磷酸雌莫司汀和己烯雌酚二磷酸酯的作用。
Eur J Pharmacol. 1981 Nov 19;76(1):87-91. doi: 10.1016/0014-2999(81)90013-3.
2
Role of changes in membrane lipid structure in the action of 1,25-dihydroxyvitamin D3.膜脂质结构变化在1,25 - 二羟基维生素D3作用中的角色
Fed Proc. 1982 Jan;41(1):72-7.
3
Non-genomic effects of steroids. Interactions of steroid molecules with membrane structures and functions.类固醇的非基因组效应。类固醇分子与膜结构及功能的相互作用。
Biochim Biophys Acta. 1983 Aug 11;737(3-4):409-42. doi: 10.1016/0304-4157(83)90008-4.
4
An early effect of cortisol, previous to its glycogenogenic action.皮质醇在其糖原生成作用之前的早期效应。
Horm Metab Res. 1981 Nov;13(11):609-11. doi: 10.1055/s-2007-1019351.
5
An interaction of testosterone with cell membranes.睾酮与细胞膜的相互作用。
Horm Metab Res. 1984 Sep;16(9):475-7. doi: 10.1055/s-2007-1014823.
6
Interaction of glucocorticoids with glucagon and epinephrine in the control of gluconeogenesis and glycogenolysis in liver and of lipolysis in adipose tissue.糖皮质激素与胰高血糖素及肾上腺素在肝脏糖异生和糖原分解以及脂肪组织脂肪分解调控中的相互作用。
J Biol Chem. 1972 Jun 10;247(11):3579-88.
7
Estrogen stimulation of phosphatidylinositol metabolism in mouse uterine tissue.雌激素对小鼠子宫组织中磷脂酰肌醇代谢的刺激作用。
Endocrinology. 1987 Sep;121(3):1083-8. doi: 10.1210/endo-121-3-1083.
8
Estrogen receptors and androgen receptors in the mammalian liver.哺乳动物肝脏中的雌激素受体和雄激素受体。
J Steroid Biochem. 1987;27(4-6):1109-18. doi: 10.1016/0022-4731(87)90197-x.
9
1,25 Dihydroxyvitamin D increases hepatocyte cytosolic calcium levels. A potential regulator of vitamin D-25-hydroxylase.1,25-二羟基维生素D可提高肝细胞胞质钙水平。维生素D-25-羟化酶的一种潜在调节因子。
J Clin Invest. 1986 May;77(5):1622-6. doi: 10.1172/JCI112478.
10
An early effect of estradiol at hepatic level, previous to its protein synthesis activation.在其激活蛋白质合成之前，雌二醇在肝脏水平产生的早期效应。
Int J Biochem. 1987;19(1):93-6. doi: 10.1016/0020-711x(87)90129-7.

孕酮和雌二醇可增加单个大鼠肝细胞中的胞质钙离子浓度。

Progesterone and oestradiol increase cytosolic Ca2+ in single rat hepatocytes.

作者信息

Sanchez-Bueno A, Sancho M J, Cobbold P H

机构信息

Department of Human Anatomy and Cell Biology, University of Liverpool, U.K.

出版信息

Biochem J. 1991 Nov 15;280 ( Pt 1)(Pt 1):273-6. doi: 10.1042/bj2800273.

DOI:10.1042/bj2800273
PMID:1741753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1130631/
Abstract

Progesterone (300-400 microM) and oestradiol (25-200 microM) induce a prompt rise in the cytosolic free Ca2+ concentration (free Ca) in single rat hepatocytes, but testosterone, cortisol and dexamethasone do not. These increases are dependent on the presence of extracellular Ca2+. Both progesterone and oestradiol block phenylephrine-induced free Ca oscillations. These data suggest a certain specificity of the response of free Ca to steroids and may explain some of the non-genomic effects of these steroids on hepatocytes.

摘要

孕酮（300 - 400微摩尔）和雌二醇（25 - 200微摩尔）可使单个大鼠肝细胞胞质游离钙离子浓度（游离钙）迅速升高，但睾酮、皮质醇和地塞米松则不会。这些升高依赖于细胞外钙离子的存在。孕酮和雌二醇均可阻断去氧肾上腺素诱导的游离钙振荡。这些数据表明游离钙对类固醇的反应具有一定特异性，这可能解释了这些类固醇对肝细胞的一些非基因组效应。