孕酮和雌二醇可增加单个大鼠肝细胞中的胞质钙离子浓度。
Progesterone and oestradiol increase cytosolic Ca2+ in single rat hepatocytes.
作者信息
Sanchez-Bueno A, Sancho M J, Cobbold P H
机构信息
Department of Human Anatomy and Cell Biology, University of Liverpool, U.K.
出版信息
Biochem J. 1991 Nov 15;280 ( Pt 1)(Pt 1):273-6. doi: 10.1042/bj2800273.
Abstract
Progesterone (300-400 microM) and oestradiol (25-200 microM) induce a prompt rise in the cytosolic free Ca2+ concentration (free Ca) in single rat hepatocytes, but testosterone, cortisol and dexamethasone do not. These increases are dependent on the presence of extracellular Ca2+. Both progesterone and oestradiol block phenylephrine-induced free Ca oscillations. These data suggest a certain specificity of the response of free Ca to steroids and may explain some of the non-genomic effects of these steroids on hepatocytes.
摘要
孕酮（300 - 400微摩尔）和雌二醇（25 - 200微摩尔）可使单个大鼠肝细胞胞质游离钙离子浓度（游离钙）迅速升高，但睾酮、皮质醇和地塞米松则不会。这些升高依赖于细胞外钙离子的存在。孕酮和雌二醇均可阻断去氧肾上腺素诱导的游离钙振荡。这些数据表明游离钙对类固醇的反应具有一定特异性，这可能解释了这些类固醇对肝细胞的一些非基因组效应。
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本文引用的文献
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Non-genomic effects of steroids. Interactions of steroid molecules with membrane structures and functions.类固醇的非基因组效应。类固醇分子与膜结构及功能的相互作用。
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