Kok H P, Kotte A N T J, Crezee J
a Department of Radiation Oncology , Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.
b Department of Radiotherapy , University Medical Center Utrecht , Utrecht , The Netherlands.
Int J Hyperthermia. 2017 Sep;33(6):593-607. doi: 10.1080/02656736.2017.1295323. Epub 2017 Mar 8.
Hyperthermia treatment planning using dedicated simulations of power and temperature distributions is very useful to assist in hyperthermia applications. This paper describes an advanced treatment planning software package for a wide variety of applications.
The in-house developed C++ software package Plan2Heat runs on a Linux operating system. Modules are available to perform electric field and temperature calculations for many heating techniques. The package also contains optimisation routines, post-treatment evaluation tools and a sophisticated thermal model enabling to account for 3D vasculature based on an angiogram or generated artificially using a vessel generation algorithm. The use of the software is illustrated by a simulation of a locoregional hyperthermia treatment for a pancreatic cancer patient and a spherical tumour model heated by interstitial hyperthermia, with detailed 3D vasculature included.
The module-based set-up makes the software flexible and easy to use. The first example demonstrates that treatment planning can help to focus the heating to the tumour. After optimisation, the simulated absorbed power in the tumour increased with 50%. The second example demonstrates the impact of accurately modelling discrete vasculature. Blood at body core temperature entering the heated volume causes relatively cold tracks in the heated volume, where the temperature remains below 40 °C.
A flexible software package for hyperthermia treatment planning has been developed, which can be very useful in many hyperthermia applications. The object-oriented structure of the source code allows relatively easy extension of the software package with additional tools when necessary for future applications.
使用功率和温度分布的专用模拟进行热疗治疗计划对于辅助热疗应用非常有用。本文描述了一种适用于多种应用的先进治疗计划软件包。
内部开发的C++软件包Plan2Heat在Linux操作系统上运行。有模块可用于对多种加热技术进行电场和温度计算。该软件包还包含优化程序、治疗后评估工具以及一个复杂的热模型，能够基于血管造影或使用血管生成算法人工生成的血管造影来考虑三维血管系统。通过对一名胰腺癌患者的局部热疗治疗模拟以及一个通过间质热疗加热的球形肿瘤模型（包括详细的三维血管系统）来说明该软件的使用。
基于模块的设置使软件灵活且易于使用。第一个例子表明治疗计划有助于将加热集中在肿瘤上。优化后，肿瘤中模拟的吸收功率增加了50%。第二个例子展示了精确模拟离散血管系统的影响。进入加热区域的体核温度的血液在加热区域导致相对较冷的轨迹，其中温度保持在40°C以下。
已开发出一种用于热疗治疗计划的灵活软件包，其在许多热疗应用中可能非常有用。源代码的面向对象结构允许在未来应用需要时相对容易地用附加工具扩展软件包。
