a Department of Physics , Southern Illinois University , Carbondale , IL , USA.
b Department of Physics & Astronomy , Louisiana State University , LA , USA.
Int J Hyperthermia. 2017 Nov;33(7):779-784. doi: 10.1080/02656736.2017.1312562. Epub 2017 Apr 17.
Self-controlled hyperthermia is a non-invasive technique used to kill or destroy cancer cells while preserving normal surrounding tissues. We have explored bulk magnetic Ni-Si and Ni-Al alloys as a potential thermoseeds. The structural, magnetic and magnetocaloric properties of the samples were investigated, including saturation magnetisation, Curie temperature (T), and magnetic and thermal hysteresis, using room temperature X-ray diffraction and magnetometry. The annealing time, temperature and the effects of homogenising the thermoseeds were studied to determine the functional hyperthermia applications. The bulk Ni-Si and Ni-Al binary alloys have Curie temperatures in the desired range, 316 K-319 K (43 °C-46 °C), which is suitable for magnetic hyperthermia applications. We have found that T strictly follows a linear trend with doping concentration over a wide range of temperature. The magnetic ordering temperature and the magnetic properties can be controlled through substitution in these binary alloys.
自控制热疗是一种非侵入性技术，用于杀死或破坏癌细胞，同时保留正常周围组织。我们探索了块状磁镍-硅和镍-铝合金作为潜在的热种子。使用室温 X 射线衍射和磁强计研究了样品的结构、磁性和磁热滞回线，包括饱和磁化强度、居里温度 (T)、磁滞和热滞。研究了退火时间、温度以及热种子均化的影响，以确定功能性热疗的应用。块状镍-硅和镍-铝二元合金的居里温度在所需范围内，316K-319K（43°C-46°C），适用于磁热疗应用。我们发现 T 在很宽的温度范围内严格遵循掺杂浓度的线性趋势。通过在这些二元合金中进行替代，可以控制磁有序温度和磁性。
