Yamashita Takehiro, Asaoka Ryo, Kii Yuya, Terasaki Hiroto, Murata Hiroshi, Sakamoto Taiji
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.
PLoS One. 2017 May 25;12(5):e0177247. doi: 10.1371/journal.pone.0177247. eCollection 2017.
The location of the peaks of the circumpapillary retinal nerve fiber layer (cpRNFL) thickness is affected by several ocular parameters. In this study, we have generated equations that can determine the peaks of the cpRNFL. This study was a prospective, observational, cross sectional study of 118 healthy right eyes. The axial length, optic disc tilt, superiortemporal (ST)- and inferiortemporal (IT)-peaks of the cpRNFL thickness, and angles of the ST and IT retinal arteries (RA) and veins (RV) were determined. The correlations between the location of the ST- and IT-peaks and ocular structural parameters and the sex, body height and weight were calculated. The best fit equations to generate the location of the ST/IT-peaks were determined using corrected-Akaike Information Criteria. The location of the ST-peak was 0.72+(0.40 x ST-RA)+(0.27 x ST-RV)+(0.14 x height)-(0.47 x papillo-macular-position)-(0.11 x disc tilt) with a coefficient of correlation of 0.61 (P<0.0001). The location of the IT-peak was 21.88+(0.53 x IT-RA)+(0.15 x IT-RV)+(0.041 x corneal thickness)-(1.00 x axial length) with a coefficient of correlation of 0.59 (P<0.0001). The location of ST/IT peaks is determined by different parameters of the ocular structure. These equations allow clinicians to obtain an accurate location of the peaks for a more accurate diagnosis of glaucoma.
视乳头周围视网膜神经纤维层（cpRNFL）厚度峰值的位置受多种眼部参数影响。在本研究中，我们生成了能够确定cpRNFL厚度峰值的方程。本研究是一项对118只健康右眼进行的前瞻性、观察性横断面研究。测定了眼轴长度、视盘倾斜度、cpRNFL厚度的颞上（ST）和颞下（IT）峰值，以及颞上和颞下视网膜动脉（RA）和静脉（RV）的角度。计算了颞上和颞下峰值位置与眼部结构参数以及性别、身高和体重之间的相关性。使用校正后的赤池信息准则确定了生成颞上/颞下峰值位置的最佳拟合方程。颞上峰值的位置为0.72 +（0.40×颞上RA）+（0.27×颞上RV）+（0.14×身高） - （0.47×视乳头黄斑位置） - （0.11×视盘倾斜度），相关系数为0.61（P<0.0001）。颞下峰值的位置为21.88 +（0.53×颞下RA）+（0.15×颞下RV）+（0.041×角膜厚度） - （1.00×眼轴长度），相关系数为0.59（P<0.0001）。颞上/颞下峰值的位置由眼部结构的不同参数决定。这些方程使临床医生能够获得峰值的准确位置，以便更准确地诊断青光眼。
