Yamashita Takehiro, Asaoka Ryo, Iwase Aiko, Sakai Hiroshi, Terasaki Hiroto, Sakamoto Taiji, Araie Makoto
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Department of Ophthalmology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
Jpn J Ophthalmol. 2025 Jun 9. doi: 10.1007/s10384-025-01192-5.
To evaluate the accuracy of predictive refractive error (RE) and axial length (AL) using regression analysis of fundus parameters in the Kumejima study and to identify RE- or AL-related fundus changes.
Prospective cross-sectional observational population study.
Non-mydriatic color fundus photographs (CFPs) from 1,646 right eyes of healthy Kumejima participants were analyzed. Mean red (R), green (G), and blue (B) intensities at eight locations around the optic disc and fovea were quantified, and the tessellation fundus index was calculated as R/(R + G + B). Optic disc ovality ratio, papillomacular angle, and retinal vessel angle were measured. Least absolute shrinkage and selection operator regression with leave-one-out cross-validation predicted RE and AL, validated using Pearson's correlation coefficient.
The mean ± standard deviation actual RE and AL of participants (834 men and 812 women) were -0.14±1.62 diopter and 23.50±0.88 mm. The mean ± standard deviation predicted RE and AL based on fundus parameters was -0.14±1.05 diopter and 23.50±0.48 mm, with a mean absolute error of 0.91 diopter and 0.59 mm, and the correlation coefficients between actual and predicted RE and AL were 0.63 and 0.51 (p<0.001). Eyes with a longer AL had narrower temporal vessel angles, weaker green intensities, stronger blue intensities, and increased tessellation of the fundus color (p<0.001).
RE and AL could be predicted using CFP parameters; the RE- or AL-related changes in the fundus, such as vessel angles and peripapillary color intensity, may enhance our understanding of myopia mechanisms.
在久米岛研究中，利用眼底参数的回归分析评估预测性屈光不正（RE）和眼轴长度（AL）的准确性，并识别与RE或AL相关的眼底变化。
前瞻性横断面观察性人群研究。
分析了来自久米岛健康参与者1646只右眼的免散瞳彩色眼底照片（CFP）。对视盘和黄斑周围八个位置的平均红色（R）、绿色（G）和蓝色（B）强度进行量化，并计算镶嵌眼底指数，即R/（R+G+B）。测量视盘椭圆率、视乳头黄斑角和视网膜血管角。采用最小绝对收缩和选择算子回归结合留一法交叉验证预测RE和AL，并使用Pearson相关系数进行验证。
参与者（834名男性和812名女性）的实际RE和AL的平均值±标准差分别为-0.14±1.62屈光度和23.50±0.88毫米。基于眼底参数预测的RE和AL的平均值±标准差分别为-0.14±1.05屈光度和23.50±0.48毫米，平均绝对误差分别为0.91屈光度和0.59毫米，实际与预测的RE和AL之间的相关系数分别为0.63和0.51（p<0.001）。眼轴较长的眼睛颞侧血管角较窄，绿色强度较弱，蓝色强度较强，眼底颜色的镶嵌增加（p<0.001）。
可使用CFP参数预测RE和AL；眼底与RE或AL相关的变化，如血管角和视乳头周围颜色强度，可能会增进我们对近视机制的理解。
