Bernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.
Department of Psychology, Columbia University, New York, NY, USA.
Transl Vis Sci Technol. 2024 Apr 2;13(4):27. doi: 10.1167/tvst.13.4.27.
To understand the association between anatomical parameters of healthy eyes and optical coherence tomography (OCT) circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements.
OCT cpRNFL thickness was obtained from 396 healthy eyes in a commercial reference database (RDB). The temporal quadrant (TQ), superior quadrant (SQ), inferior quadrant (IQ), and global (G) cpRNFL thicknesses were analyzed. The commercial OCT devices code these values based on percentiles (red, <1%; yellow, ≥1% and <5%), after taking age and disc area into consideration. Four anatomical parameters were assessed: fovea-to-disc distance, an estimate of axial length, and the locations of the superior and the inferior peaks of the cpRNFL thickness curve. Pearson correlation values were obtained for the parameters and the thickness measures of each of the four cpRNFL regions, and t-tests were performed between the cpRNFL thicknesses coded as abnormal (red or yellow, <5%) versus normal (≥5%).
For each of the four anatomical parameters, the correlation with the thickness of one or more of the TQ, SQ, IQ, and G regions exceeded the correlation with age or disc area. All four parameters were significantly (P < 0.001) associated with the abnormal cpRNFL values. The significant parameters were not the same for the different regions; for example, a parameter could be negatively correlated for the TQ but positively correlated with the SQ or IQ.
In addition to age and disc area, which are used for inferences in normative databases, four anatomical parameters are associated with cpRNFL thickness.
Taking these additional anatomical parameters into consideration should aid diagnostic accuracy.
了解健康眼的解剖参数与光相干断层扫描（OCT）环周视网膜神经纤维层（cpRNFL）厚度测量之间的关系。
从商业参考数据库（RDB）中获得 396 只健康眼的 OCT cpRNFL 厚度。分析颞象限（TQ）、上象限（SQ）、下象限（IQ）和全象限（G）cpRNFL 厚度。商业 OCT 设备根据年龄和视盘面积考虑后，将这些值基于百分位数（红色，<1%；黄色，≥1%和<5%）进行编码。评估了四个解剖参数：视盘到黄斑中心凹的距离、眼轴的估计值，以及 cpRNFL 厚度曲线的上、下峰值的位置。获得了参数与四个 cpRNFL 区域的厚度测量值之间的 Pearson 相关值，并对编码为异常（红色或黄色，<5%）与正常（≥5%）的 cpRNFL 厚度值进行 t 检验。
对于四个解剖参数中的每一个，与 TQ、SQ、IQ 和 G 区域中的一个或多个区域的厚度的相关性超过了与年龄或视盘面积的相关性。所有四个参数都与异常 cpRNFL 值显著相关（P<0.001）。不同区域的显著参数不同；例如，一个参数可以与 TQ 呈负相关，但与 SQ 或 IQ 呈正相关。
除了用于规范数据库推断的年龄和视盘面积外，还有四个解剖参数与 cpRNFL 厚度相关。
杨硕
