紧密联系：代谢调节与细胞信号传导界面处的肌醇焦磷酸
Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling.
作者信息
Shears Stephen B
机构信息
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
出版信息
J Cell Physiol. 2018 Mar;233(3):1897-1912. doi: 10.1002/jcp.26017. Epub 2017 Jun 15.
Abstract
Inositol pyrophosphates are small, diffusible signaling molecules that possess the most concentrated three-dimensional array of phosphate groups in Nature; up to eight phosphates are crammed around a six-carbon inositol ring. This review discusses the physico-chemical properties of these unique molecules, and their mechanisms of action. Also provided is information on the enzymes that regulate the levels and hence the signaling properties of these molecules. This review pursues the idea that many of the biological effects of inositol pyrophosphates can be rationalized by their actions at the interface of cell signaling and metabolism that is essential to cellular and organismal homeostasis.
摘要
肌醇焦磷酸是一类小分子、可扩散的信号分子，其拥有自然界中最密集的三维磷酸基团阵列；多达八个磷酸基团围绕着一个六碳肌醇环排列。本综述讨论了这些独特分子的物理化学性质及其作用机制。还提供了有关调节这些分子水平及其信号特性的酶的信息。本综述探讨了这样一种观点，即肌醇焦磷酸的许多生物学效应可以通过它们在细胞信号传导与代谢的界面上的作用来解释，而这对于细胞和机体的稳态至关重要。
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