Liu Ren-Feng, Chen Chun-Bing, Kuo Tseng-Tong, Chung Wen-Hung
Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Taipei, Linkou, and Keelung, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
J Cutan Pathol. 2017 Sep;44(9):776-780. doi: 10.1111/cup.12967. Epub 2017 Jun 23.
Idiopathic lymphoplasmacellular mucositis (ILPM) is a group of disorders histologically characterized by dense infiltrates of lymphocytes and plasma cells in submucosa. These lesions were initially observed on the glans penis and vulva, and later on buccal mucosa, lips, gingiva, tongue, epiglottis, larynx and other mucosal surfaces have also been reported. We have reviewed the previously reported cases of ILPM with lip involvement, outlining the clinical presentation, treatment and outcome of the entity to date. The etiology of ILPM is unknown, and the diagnosis is largely one of exclusion. To date, no consensus or consistently effective treatment for ILPM is available. Herein, we report an 18-year-old woman presented with markedly swollen lips with severe erosions, bleeding and yellow to black crusts who was diagnosed to have ILPM by histopathological study. The case occurred on rare lip site with an unusual appearance. Various treatment modalities were tried, but the responses were unsatisfactory and the lesion only responded to long-term administration of oral steroids.
特发性淋巴浆细胞性黏膜炎（ILPM）是一组组织学上以黏膜下层淋巴细胞和浆细胞密集浸润为特征的疾病。这些病变最初在阴茎头和外阴被观察到，后来颊黏膜、嘴唇、牙龈、舌头、会厌、喉部及其他黏膜表面也有报道。我们回顾了先前报道的累及唇部的ILPM病例，概述了该疾病迄今为止的临床表现、治疗及转归。ILPM的病因尚不清楚，诊断主要是排除性诊断。迄今为止，尚无针对ILPM的共识性或始终有效的治疗方法。在此，我们报告一名18岁女性，其嘴唇明显肿胀，伴有严重糜烂、出血及黄黑色痂皮，经组织病理学研究诊断为ILPM。该病例发生在罕见的唇部部位，外观异常。尝试了各种治疗方式，但效果均不理想，病变仅对长期口服类固醇有反应。
