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特发性淋巴细胞-浆细胞性黏膜炎;诊断困境

Idiopathic Lympho-Plasma Cellular Mucositis; A Diagnostic Predicament.

作者信息

Sankar Roshna, Tomar Arushi, John Sharon, Verma Veerendra, Gupta Shalini

机构信息

Department of Oral & Maxillofacial Pathology and Oral Microbiology, King George's Medical University, Lucknow, India.

Department of ENT, King George's Medical University, Lucknow, 226003 India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2024 Aug;76(4):3519-3523. doi: 10.1007/s12070-024-04593-z. Epub 2024 Mar 18.

DOI:10.1007/s12070-024-04593-z
PMID:39130237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11306671/
Abstract

The term "idiopathic lymphoplasmacellular mucositis" (ILPM) refers to a set of conditions marked by extensive lymphocyte and plasma cell infiltrates in the submucosa which can involve the oral cavity, upper respiratory tract and the genital epithelium. There is no recognized cause of ILPM, and the diagnosis is mostly done on an exclusion basis. Herein, we report a 32-year-old man presented with an erosive ulcerated lesion on the hard palate and review the literature regarding the possible differential diagnosis including squamous cell carcinoma. We also reviewed the previously reported cases of ILPM with palatal involvement to summarise clinical presentation, treatment, and outcome of the entity to date.

摘要

术语“特发性淋巴浆细胞性黏膜炎”(ILPM)指的是一组以黏膜下层广泛淋巴细胞和浆细胞浸润为特征的病症,可累及口腔、上呼吸道和生殖上皮。ILPM的病因尚不明确,诊断主要基于排除法。在此,我们报告一名32岁男性,其硬腭出现糜烂性溃疡性病变,并回顾了包括鳞状细胞癌在内的可能鉴别诊断的文献。我们还回顾了先前报道的腭部受累的ILPM病例,以总结该疾病目前的临床表现、治疗方法及预后情况。

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本文引用的文献

1
Unusual presentation of maxillary plasma cell gingivitis mistakenly treated as aggressive periodontitis. (A case report).上颌浆细胞性龈炎的不寻常表现被误诊为侵袭性牙周炎。(病例报告)
Int J Surg Case Rep. 2022 Apr;93:106998. doi: 10.1016/j.ijscr.2022.106998. Epub 2022 Mar 30.
2
Unusual oral mucositis.罕见口腔黏膜炎。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Aug;134(2):128-134. doi: 10.1016/j.oooo.2021.12.001. Epub 2021 Dec 11.
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Plasma Cell Mucositis of the Hard Palate.硬腭浆细胞性黏膜炎
Ear Nose Throat J. 2021 Mar;100(3):145-146. doi: 10.1177/0145561319872732. Epub 2019 Sep 23.
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IgG-4 Related Disease: An Introduction.IgG4相关性疾病:简介
Mo Med. 2018 May-Jun;115(3):253-256.
5
Idiopathic lymphoplasmacellular mucositis of the lips: A case report and review of the literature.唇部特发性淋巴浆细胞性黏膜炎:一例报告并文献复习
J Cutan Pathol. 2017 Sep;44(9):776-780. doi: 10.1111/cup.12967. Epub 2017 Jun 23.
6
Plasma cell mucositis with gingival enlargement and severe periodontitis.伴有牙龈肿大和严重牙周炎的浆细胞性口腔黏膜炎
J Indian Soc Periodontol. 2014 May;18(3):379-84. doi: 10.4103/0972-124X.134583.
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Idiopathic lymphoplasmacellular mucositis-dermatitis.特发性淋巴浆细胞性黏膜皮炎
J Cutan Pathol. 2010 Apr;37(4):426-31. doi: 10.1111/j.1600-0560.2009.01371.x. Epub 2009 Jul 15.
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Plasma cell mucositis of the oral cavity: report of a case and review of the literature.口腔浆细胞性黏膜炎:一例报告及文献复习
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Dec;106(6):853-60. doi: 10.1016/j.tripleo.2008.08.016. Epub 2008 Oct 16.
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Dermatol Online J. 2003 Dec;9(5):15.
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[Chronic benign circumscript plasmocytic balanoposthitis].[慢性良性局限性浆细胞性龟头炎]
Dermatologica. 1952;105(1):1-7.