Taylor J, Weinberg R, Kawaoka Y, Webster R G, Paoletti E
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201.
Vaccine. 1988 Dec;6(6):504-8. doi: 10.1016/0264-410x(88)90101-6.
Fowlpox virus, the prototypic virus of the genus Avipoxvirus has a natural host range limited to avian species. As such, fowlpox virus provides a suitable candidate for the development of a species-specific recombinant viral vector. This paper reports the development of a fowlpox virus recombinant expressing the haemagglutinin molecule from a highly virulent avian influenza virus. On immunization of chickens and turkeys with the recombinant, protection is afforded against a lethal challenge with either the homologous or a heterologous influenza virus strain.
