Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.
Graduiertenschule MAterials Science IN MainZ, Germany.
Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9608-9613. doi: 10.1002/anie.201702624. Epub 2017 Jul 6.
Achieving precise control over the morphology and function of polymeric nanostructures during self-assembly remains a challenge in materials as well as biomedical science, especially when independent control over particle properties is desired. Herein, we report on nanostructures derived from amphiphilic block copolypept(o)ides by secondary-structure-directed self-assembly, presenting a strategy to adjust core polarity and function separately from particle preparation in a bioreversible manner. The peptide-inherent process of secondary-structure formation allows for the synthesis of spherical and worm-like core-cross-linked architectures from the same block copolymer, introducing a simple yet powerful approach to versatile peptide-based core-shell nanostructures.
在自组装过程中实现对聚合物纳米结构的形态和功能的精确控制仍然是材料科学和生物医学科学的一个挑战，特别是当需要对颗粒性质进行独立控制时。在此，我们报告了通过二级结构导向自组装从两亲性嵌段多肽得到的纳米结构，提出了一种策略，以生物可逆的方式从粒子制备中分别独立地调整核极性和功能。多肽固有的二级结构形成过程允许从同一种嵌段共聚物合成球形和蠕虫状核交联结构，为基于多肽的多功能核壳纳米结构引入了一种简单而强大的方法。
