Yadav Snehlata, Narasimhan Balasubramanian, Kaur Harmeet
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.
Anticancer Agents Med Chem. 2016;16(11):1403-1425. doi: 10.2174/1871520616666151103113412.
Cancer is one of the deadliest diseases nowadays and is a great topic for research as the challenging task is to develop new entities with selectivity towards cancerous cells. Heterocyclic compounds are of great importance in medicinal chemistry as they possess an extensive range of therapeutic applications. Benzimidazole is one such important heterocyclic organic compound having structural analogy to nucleotides found in human body and hence is an important pharmacophore in medicinal chemistry. A variety of marketed drugs containing benzimidazole are thiabendazole, flubendazole (anthelmintic), astmizole (antihistaminic), lansoprazole and omeprazole (antiulcerative). In the light of the above facts, this review is an attempt to summarize the collective contributions from the authors around the world in the field of anticancer agents. This review highlights synthetic schemes and anticancer activity results of the research done in the past years.
癌症是当今最致命的疾病之一，也是一个重要的研究课题，因为挑战性的任务是开发对癌细胞具有选择性的新实体。杂环化合物在药物化学中非常重要，因为它们具有广泛的治疗应用。苯并咪唑就是这样一种重要的杂环有机化合物，其结构与人体中发现的核苷酸类似，因此是药物化学中的一个重要药效基团。多种含苯并咪唑的上市药物有噻苯达唑、氟苯达唑（驱虫药）、阿司咪唑（抗组胺药）、兰索拉唑和奥美拉唑（抗溃疡药）。鉴于上述事实，本综述旨在总结世界各地作者在抗癌药物领域的集体贡献。本综述重点介绍了过去几年所做研究的合成方案和抗癌活性结果。
