新型2-取代-5-硝基苯并咪唑衍生物作为靶向VEGFR-2和c-Met的抗癌剂的分子对接模拟、合成及三维药效团研究 - Suppr

Molecular docking simulation, synthesis and 3D pharmacophore studies of novel 2-substituted-5-nitro-benzimidazole derivatives as anticancer agents targeting VEGFR-2 and c-Met.

作者信息

Ibrahim Heba A, Awadallah Fadi M, Refaat Hanan M, Amin Kamilia M

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University In Egypt, Cairo, Egypt.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt.

出版信息

Bioorg Chem. 2018 Apr;77:457-470. doi: 10.1016/j.bioorg.2018.01.014. Epub 2018 Jan 31.

DOI:10.1016/j.bioorg.2018.01.014

PMID:29453077

Abstract

摘要

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Molecular docking simulation, synthesis and 3D pharmacophore studies of novel 2-substituted-5-nitro-benzimidazole derivatives as anticancer agents targeting VEGFR-2 and c-Met.新型2-取代-5-硝基苯并咪唑衍生物作为靶向VEGFR-2和c-Met的抗癌剂的分子对接模拟、合成及三维药效团研究

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Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2.发现含苯并咪唑片段的喹唑啉-4-胺作为c-Met和VEGFR-2的双重抑制剂

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Design, synthesis and in vitro evaluation of 6-amide-2-aryl benzoxazole/benzimidazole derivatives against tumor cells by inhibiting VEGFR-2 kinase.设计、合成及 6-酰胺-2-芳基苯并恶唑/苯并咪唑衍生物通过抑制 VEGFR-2 激酶对肿瘤细胞的体外评价。

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Design, synthesis and molecular modeling study for some new 2-substituted benzimidazoles as dual inhibitors for VEGFR-2 and c-Met.设计、合成及分子模拟研究新型 2-取代苯并咪唑衍生物作为 VEGFR-2 和 c-Met 的双重抑制剂。

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Molecular docking simulation, synthesis and 3D pharmacophore studies of novel 2-substituted-5-nitro-benzimidazole derivatives as anticancer agents targeting VEGFR-2 and c-Met.

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