干扰素诱导跨膜蛋白 3 调节人肺腺癌的生长和侵袭。
Interferon induced transmembrane protein 3 regulates the growth and invasion of human lung adenocarcinoma.
机构信息
Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Jinan, China.
Department of Pulmonary Medicine, The First Affiliated Hospital of Baotou Medical College, Baotou, China.
出版信息
Thorac Cancer. 2017 Jul;8(4):337-343. doi: 10.1111/1759-7714.12451. Epub 2017 May 23.
BACKGROUND
Interferon induced transmembrane protein 3 (IFITM3) plays an important role in the tumorigenesis and progression of multiple cancers. This study investigated the expression and function of IFITM3 in human lung adenocarcinoma.
METHODS
Fifty human lung adenocarcinoma tissues were collected. IFITM3 expression was assessed by immunohistochemical staining. The clinicopathologic characteristics of all patients were analyzed.
RESULTS
IFITM3 was mainly detected in the cytoplasm of advanced cancer tissues and its expression was correlated with tumor malignancy grade. Knockdown of IFITM3 in vitro markedly inhibited the proliferation and invasion of lung adenocarcinoma cells.
CONCLUSION
IFITM3 represents a potential therapeutic target for the treatment of lung adenocarcinoma.
背景
干扰素诱导跨膜蛋白 3（IFITM3）在多种癌症的发生和发展中起着重要作用。本研究探讨了 IFITM3 在人肺腺癌中的表达和功能。
方法
收集 50 例人肺腺癌组织。采用免疫组织化学染色法检测 IFITM3 的表达。分析所有患者的临床病理特征。
结果
IFITM3 主要在晚期癌组织的细胞质中检测到，其表达与肿瘤恶性程度相关。体外敲低 IFITM3 明显抑制肺腺癌细胞的增殖和侵袭。
结论
IFITM3 可能成为肺腺癌治疗的潜在靶点。
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