Department of Otolaryngology-Head and Neck Surgery, Federal University of Sao Paulo, Sao Paulo, Brazil.
Int Forum Allergy Rhinol. 2017 Jul;7(7):712-717. doi: 10.1002/alr.21948. Epub 2017 May 23.
Continuous airflow in the upper airway can cause discomfort, leading to nasopharyngeal complaints. The aim of the present study is to evaluate the acute effects of continuous positive upper-airway pressure on nasal patency in awake normal subjects.
Twenty-seven adults (17 men; 10 women; age range, 18 to 43 years) were exposed to continuous airway pressure (20 cmH O) in the nasal cavity, delivered by a continuous positive airway pressure (CPAP) device through a nasal mask for 2 hours. Visual analogue scale (VAS) of nasal obstruction, Nasal Obstruction Symptom Evaluation (NOSE) modified scale, acoustic rhinometry (AR), and peak nasal inspiratory flow (PF) were measured before and after the use of CPAP.
There was an increase in nasal obstruction scores both on the VAS (p < 0.05) and on the NOSE scale (p < 0.05), as well as a reduction in nasal cavity volume on AR (p < 0.05) and a decline in PF (p < 0.05). Subjects were stratified into 2 groups: with and without symptoms of allergic rhinitis. Nasal parameters were significantly worse in the rhinitis group, with higher nasal obstruction scores on the VAS (p = 0.001) and NOSE scale (p < 0.001) and decreased PF (p < 0.001).
Acute exposure to positive pressure via CPAP is associated with subjective and objective reductions in nasal patency. In individuals with allergic nasal symptoms, deterioration is even more severe than in patients without these symptoms.
上气道持续气流可能会引起不适，导致鼻咽部不适。本研究旨在评估清醒正常受试者持续气道正压对上气道通畅性的急性影响。
27 名成年人（17 名男性；10 名女性；年龄 18-43 岁）通过鼻罩接受 CPAP 设备输送的 20cmH2O 持续气道压力 2 小时。分别在 CPAP 使用前后使用视觉模拟量表（VAS）评估鼻塞、改良鼻阻塞症状评估量表（NOSE）、声鼻反射（AR）和鼻峰吸气流速（PF）。
VAS（p<0.05）和 NOSE 评分（p<0.05）均增加，AR 鼻腔容积减小（p<0.05），PF 下降（p<0.05）。受试者分为两组：有和无过敏性鼻炎症状。鼻炎组的鼻腔参数明显更差，VAS（p=0.001）和 NOSE 评分（p<0.001）的鼻塞评分更高，PF 降低（p<0.001）。
CPAP 急性暴露与鼻通气的主观和客观下降有关。在有过敏性鼻症状的个体中，恶化甚至比没有这些症状的患者更严重。
