Chaidas Konstantinos, Lamprou Kallirroi, Munnings Amberley, Stradling John R, Nickol Annabel H
Ear, Nose and Throat Department, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.
Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 7LE, UK.
Life (Basel). 2022 Feb 17;12(2):305. doi: 10.3390/life12020305.
The role of nasal symptoms in continuous positive airway pressure (CPAP) tolerance is not completely clear. This study aimed to investigate the association between CPAP usage and nasal symptoms, either prior to, or developing during, CPAP use in patients with obstructive sleep apnoea (OSA). Two hundred thirty patients were studied and divided into high-, low-, and non-CPAP users. Nasal symptoms and related quality of life parameters were evaluated prior to CPAP initiation and after three months. We also investigated predictive factors for CPAP usage. Non-CPAP users had significantly worse baseline scores for runny nose compared with high and low users (1.34 vs. 0.68 and 0.75, respectively, = 0.006). There were no other significant differences between the groups. Runny nose was an independent predictive factor for lower CPAP usage ( = 0.036). An evaluation after three months showed worsening in runny nose score in high-CPAP users ( = 0.025) but not in low- and non-users. There were no significant changes in other nasal symptoms. Our study demonstrates that nasal symptoms were very common in this population but rhinorrhoea was the only symptom associated with poorer CPAP adherence. Moreover, rhinorrhoea worsened after a three-month trial of high-CPAP usage.
鼻症状在持续气道正压通气（CPAP）耐受性中的作用尚不完全清楚。本研究旨在调查阻塞性睡眠呼吸暂停（OSA）患者在使用CPAP之前或使用过程中出现的鼻症状与CPAP使用之间的关联。对230名患者进行了研究，并将其分为高、低和非CPAP使用者。在开始使用CPAP之前和三个月后，对鼻症状及相关生活质量参数进行了评估。我们还调查了CPAP使用的预测因素。与高和低使用者相比，非CPAP使用者的流鼻涕基线评分显著更差（分别为1.34 vs. 0.68和0.75，P = 0.006）。各组之间没有其他显著差异。流鼻涕是CPAP低使用量的一个独立预测因素（P = 0.036）。三个月后的评估显示，高CPAP使用者的流鼻涕评分恶化（P = 0.025），而低使用者和非使用者则没有。其他鼻症状没有显著变化。我们的研究表明，鼻症状在该人群中非常常见，但流涕是唯一与CPAP依从性较差相关的症状。此外，在高CPAP使用三个月的试验后，流涕情况恶化。
