Xiong Shun, Han Wei, Liu Weiwei, Wu Lihong, Liu Jun Xia, Gao Yang, Huang Guoning
a Chongqing Reproductive and Genetics Institute , Chongqing , China.
b Chongqing Obstetrics and Gynecology Hospital , Chongqing , China.
Hum Fertil (Camb). 2018 Sep;21(3):204-211. doi: 10.1080/14647273.2017.1324181. Epub 2017 May 26.
The purpose of this study was to determine the incidence of oocytes with severe ovoid zona pellucida (ZP), investigate the development potential of their sibling oocytes and the clinical outcomes from affected cycles. The data were collected from our medical records. Cycles having at least one oocyte with severe ovoid ZP were defined as the 'severe ovoid group', cycles having at least one oocyte with mild ovoid ZP were defined as the 'mild ovoid group', whereas cycles without oocytes with ovoid ZPs were defined as the 'control group' (n = 150 for each group). The results showed that sibling embryos in the 'severe ovoid group' were characterized by delayed development and lower available embryo rate. The implantation, clinical pregnancy and live birth rates in this group were also significantly lower than that in the other two groups. There were five cycles in which only one embryo with severe ovoid ZP was transferred and two healthy babies were born. The mild ovoid group showed comparable embryo development and clinical outcomes compared with the control group. This study suggests that cycles containing oocytes with severe ovoid ZPs had delayed embryo development, lower available embryo rate, compromised implantation, clinical pregnancy and live birth rates.
本研究的目的是确定具有严重卵圆形透明带（ZP）的卵母细胞的发生率，研究其同胞卵母细胞的发育潜力以及受影响周期的临床结局。数据从我们的病历中收集。至少有一个卵母细胞具有严重卵圆形ZP的周期被定义为“严重卵圆形组”，至少有一个卵母细胞具有轻度卵圆形ZP的周期被定义为“轻度卵圆形组”，而没有卵圆形ZP卵母细胞的周期被定义为“对照组”（每组n = 150）。结果显示，“严重卵圆形组”中的同胞胚胎具有发育延迟和可用胚胎率较低的特征。该组的着床率、临床妊娠率和活产率也显著低于其他两组。有5个周期仅移植了一个具有严重卵圆形ZP的胚胎，并且出生了2名健康婴儿。与对照组相比，轻度卵圆形组显示出相当的胚胎发育和临床结局。本研究表明，含有严重卵圆形ZP卵母细胞的周期胚胎发育延迟，可用胚胎率较低，着床、临床妊娠和活产率受损。
