Mirboluk Amir Ahmad, Rohani Farzaneh, Asadi Ramin, Eslamian Mohammad Reza
Aliasghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran.
Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran; Department of Pediatrics Endocrinology and Metabolism, Ali Asghar Children's Hospital, Iran University of Medical Sciences, Tehran,Iran.
Diabetes Metab Syndr. 2017 Dec;11 Suppl 2:S623-S625. doi: 10.1016/j.dsx.2017.04.015. Epub 2017 Apr 15.
Metabolism of thyroid hormones is influenced by acute systemic illnesses including diabetic ketoacidosis. In these cases T3 level is usually decreased and this condition is called "low T3 syndrome" which is usually reversed by treating the under lying Disease.
thyroid function test analysis before and after diabetic ketoacidosis treatment.
In this cross sectional study thyroid function tests were analyzed in 16 diabetic ketoacidosis patients according to American diabetic association before and after insulin therapy.
mean triiodothyronine (T3) level before and after ketoacidosis treatment were 63.2±28.2ng/dl/and 78.5±26.2ng/dl (P. value 0.00) respectively and the mean thyroxin level (T4) before and after ketoacidosis were 3.18±1.4ng/dl and 5.17±2.4ng/dl (P. value=0.00) .Mean thyrotropin (TSH) level and triiodothyronine uptake (T3RU) before and after treatment showed no significant difference.
Diabetic ketoacidosis is a sever systemic disease which along with reduction in T3 level, T4 level is also decreased and TSH level is normal. The changes in Thyroid hormones are reversed to normal after treatment of ketoacidosis so it is recommended in interpreting results of TFT in these patients we should consider these facts and thyroid function test should be repeated after treatment.
甲状腺激素的代谢受包括糖尿病酮症酸中毒在内的急性全身性疾病影响。在这些情况下，T3水平通常会降低，这种情况被称为“低T3综合征”，通常通过治疗基础疾病得以逆转。
分析糖尿病酮症酸中毒治疗前后的甲状腺功能测试。
在这项横断面研究中，根据美国糖尿病协会的标准，对16例糖尿病酮症酸中毒患者在胰岛素治疗前后的甲状腺功能测试进行了分析。
酮症酸中毒治疗前后三碘甲状腺原氨酸（T3）的平均水平分别为63.2±28.2ng/dl和78.5±26.2ng/dl（P值为0.00），酮症酸中毒前后甲状腺素（T4）的平均水平分别为3.18±1.4ng/dl和5.17±2.4ng/dl（P值=0.00）。治疗前后促甲状腺激素（TSH）的平均水平和三碘甲状腺原氨酸摄取率（T3RU）无显著差异。
糖尿病酮症酸中毒是一种严重的全身性疾病，除T3水平降低外，T4水平也降低，而TSH水平正常。酮症酸中毒治疗后甲状腺激素的变化恢复正常，因此建议在解读这些患者的甲状腺功能测试结果时应考虑这些因素，且治疗后应重复进行甲状腺功能测试。
