Rubin D H, Eaton M A, Anderson A O
Department of Medicine, University of Pennsylvania, Philadelphia 19104.
Microb Pathog. 1986 Feb;1(1):79-87. doi: 10.1016/0882-4010(86)90034-3.
Reovirus type 1, strain Lang, and type 3, strain Dearing, induced site-specific intestinal lesions in the adult mouse after intravenous inoculation. Reovirus type 1 caused inflammation and epithelial changes such as loss of nuclear polarity, villus blunting and crypt hyperplasia restricted to the ileum. In contrast, reovirus type 3 induced duodenitis, jejunitis, and ulcerative colitis. In the duodenum and jejunum, the epithelial cells appeared normal, but hemorrhage and inflammation in the lamina propria was present. In the colon, superficial ulceration, crypt abscesses, and intraluminal hemorrhage was observed. Segregation analysis using reassortant clones derived from reoviruses 1 and 3, suggested the viral hemagglutinin, encoded by genome segment S1, to be the major viral determinant of site specific intestinal disease following intravenous inoculation.
1型呼肠孤病毒Lang株和3型呼肠孤病毒Dearing株经静脉接种后，可在成年小鼠体内引发特定部位的肠道病变。1型呼肠孤病毒引起炎症和上皮细胞变化，如核极性丧失、绒毛变钝和隐窝增生，且这些病变仅限于回肠。相比之下，3型呼肠孤病毒可诱发十二指肠炎症、空肠炎和溃疡性结肠炎。在十二指肠和空肠中，上皮细胞看似正常，但固有层存在出血和炎症。在结肠中，观察到表面溃疡、隐窝脓肿和管腔内出血。使用源自1型和3型呼肠孤病毒的重配克隆进行的分离分析表明，由基因组片段S1编码的病毒血凝素是静脉接种后特定部位肠道疾病的主要病毒决定因素。
