Rubin D H, Costello T, Witzleben C L, Greene M I
J Virol. 1987 Oct;61(10):3222-6. doi: 10.1128/JVI.61.10.3222-3226.1987.
We have previously demonstrated that mammalian reovirus type 1 enters the bile and gut lumen after systemic administration. In the present study, we showed that Kupffer cell uptake is essential for the transport of reovirus into the bile. Furthermore, class II major histocompatibility antigen (I-A)-bearing cells are a major determinant for the transit of reovirus from the hepatic environment, as well as from the intestine, during the course of systemic infection. These findings may provide an approach to the control of viral pathogens that cause systemic disease by selective utilization or modification of I-A-bearing cells.
我们之前已经证明，1型哺乳动物呼肠孤病毒经全身给药后可进入胆汁和肠腔。在本研究中，我们发现库普弗细胞摄取对于呼肠孤病毒转运至胆汁中至关重要。此外，在全身感染过程中，表达II类主要组织相容性抗原（I-A）的细胞是呼肠孤病毒从肝脏环境以及从肠道转运的主要决定因素。这些发现可能为通过选择性利用或修饰表达I-A的细胞来控制引起全身性疾病的病毒病原体提供一种方法。
