The Pathogenic Transforming Growth Factor-β Overdrive Hypothesis in Aortic Aneurysms and Dissections: A Mirage?
作者信息
Mallat Ziad, Ait-Oufella Hafid, Tedgui Alain
机构信息
From the Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (Z.M.); and Institut National de la Santé et de la Recherche Médicale (Inserm) U970, Paris, France (Z.M., H.A.-O., A.T.).
出版信息
Circ Res. 2017 May 26;120(11):1718-1720. doi: 10.1161/CIRCRESAHA.116.310371.
Abstract
摘要
相似文献
1
The Pathogenic Transforming Growth Factor-β Overdrive Hypothesis in Aortic Aneurysms and Dissections: A Mirage?
Circ Res. 2017 May 26;120(11):1718-1720. doi: 10.1161/CIRCRESAHA.116.310371.
2
Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections.
Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):e78-e86. doi: 10.1161/ATVBAHA.120.313804. Epub 2020 Mar 25.
3
miR-29b participates in early aneurysm development in Marfan syndrome.
Circ Res. 2012 Jan 20;110(2):312-24. doi: 10.1161/CIRCRESAHA.111.253740. Epub 2011 Nov 23.
4
Overexpression of transforming growth factor-beta is associated with increased hyaluronan content and impairment of repair in Marfan syndrome aortic aneurysm.
Circulation. 2006 Jul 4;114(1 Suppl):I371-7. doi: 10.1161/CIRCULATIONAHA.105.000927.
5
Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models.
Annu Rev Med. 2017 Jan 14;68:51-67. doi: 10.1146/annurev-med-100415-022956.
6
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.
Nat Med. 2017 Feb;23(2):200-212. doi: 10.1038/nm.4266. Epub 2017 Jan 9.
7
Relationship between fibrillin-1 genotype and severity of cardiovascular involvement in Marfan syndrome.
Heart. 2017 Nov;103(22):1795-1799. doi: 10.1136/heartjnl-2016-310631. Epub 2017 May 3.
8
Therapy insight: aortic aneurysm and dissection in Marfan's syndrome.
Nat Clin Pract Cardiovasc Med. 2004 Nov;1(1):31-6. doi: 10.1038/ncpcardio0020.
9
New insights in the pathogenesis of aortic aneurysms.
Verh K Acad Geneeskd Belg. 2008;70(2):69-84.
10
Accelerated Marfan syndrome model recapitulates established signaling pathways.
J Thorac Cardiovasc Surg. 2020 May;159(5):1719-1726. doi: 10.1016/j.jtcvs.2019.05.043. Epub 2019 May 31.
引用本文的文献
1
Evaluation of the relationship between atherosclerotic thoracic aortic calcification and quantitative flow parameters using 4D flow MRI.
Int J Cardiovasc Imaging. 2025 Sep;41(9):1671-1695. doi: 10.1007/s10554-025-03450-6. Epub 2025 Aug 4.
2
PIASy deficiency mitigates thoracic aortic aneurysm formation via the TGF-β/Smad2/3 pathway.
J Thorac Dis. 2025 May 30;17(5):3400-3409. doi: 10.21037/jtd-2025-984. Epub 2025 May 28.
3
SLC44A2 regulates vascular smooth muscle cell phenotypic switching and aortic aneurysm.
J Clin Invest. 2024 Jun 25;134(16):e173690. doi: 10.1172/JCI173690.
4
Effects of diabetes mellitus and glycemic traits on cardiovascular morpho-functional phenotypes.
Cardiovasc Diabetol. 2023 Dec 8;22(1):336. doi: 10.1186/s12933-023-02079-w.
5
Context-dependent TGFβ family signalling in cell fate regulation.
Nat Rev Mol Cell Biol. 2023 Dec;24(12):876-894. doi: 10.1038/s41580-023-00638-3. Epub 2023 Aug 18.
6
Maintains the Contractile Phenotype of Human Aortic Vascular Smooth Muscle Cells Via Sponging and Promoting Transforming Growth Factor Beta Receptor 1 Expression in Angiotensin II-Induced Models for Aortic Dissection.
J Am Heart Assoc. 2023 Apr 4;12(7):e027425. doi: 10.1161/JAHA.122.027425. Epub 2023 Mar 28.
7
Latent TGFβ-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation.
Dis Model Mech. 2022 Mar 1;15(3). doi: 10.1242/dmm.046979. Epub 2022 Mar 28.
8
CCN2 Increases TGF-β Receptor Type II Expression in Vascular Smooth Muscle Cells: Essential Role of CCN2 in the TGF-β Pathway Regulation.
Int J Mol Sci. 2021 Dec 29;23(1):375. doi: 10.3390/ijms23010375.
9
Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease.
Front Cardiovasc Med. 2021 Nov 8;8:769343. doi: 10.3389/fcvm.2021.769343. eCollection 2021.
10
Aortic Root Dilatation Is Attenuated with Diabetes but Is Not Associated with Renal Progression in Chronic Kidney Disease.
J Pers Med. 2021 Sep 28;11(10):972. doi: 10.3390/jpm11100972.
本文引用的文献
1
Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling.
J Am Heart Assoc. 2017 Jan 24;6(1):e004968. doi: 10.1161/JAHA.116.004968.
2
Role of Microvascular Tone and Extracellular Matrix Contraction in the Regulation of Interstitial Fluid: Implications for Aortic Dissection.
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1742-7. doi: 10.1161/ATVBAHA.116.307909. Epub 2016 Jul 21.
3
Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14012-7. doi: 10.1073/pnas.1507652112. Epub 2015 Oct 22.
4
Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections.
Circ Res. 2015 Apr 10;116(8):1448-61. doi: 10.1161/CIRCRESAHA.114.304936.
5
Muscle composition is regulated by a Lox-TGFβ feedback loop.
Development. 2015 Mar 1;142(5):983-93. doi: 10.1242/dev.113449.
6
Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):911-7. doi: 10.1161/ATVBAHA.114.305150. Epub 2015 Jan 22.
7
Atenolol versus losartan in children and young adults with Marfan's syndrome.
N Engl J Med. 2014 Nov 27;371(22):2061-71. doi: 10.1056/NEJMoa1404731. Epub 2014 Nov 18.
8
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
J Clin Invest. 2014 Feb;124(2):755-67. doi: 10.1172/JCI69942. Epub 2014 Jan 9.
9
Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
J Clin Invest. 2014 Jan;124(1):448-60. doi: 10.1172/JCI69666. Epub 2013 Dec 20.
10
Modifications of chromatin dynamics control Smad2 pathway activation in aneurysmal smooth muscle cells.
Circ Res. 2013 Sep 13;113(7):881-90. doi: 10.1161/CIRCRESAHA.113.301989. Epub 2013 Jul 3.
Zotero 插件