The Pathogenic Transforming Growth Factor-β Overdrive Hypothesis in Aortic Aneurysms and Dissections: A Mirage?
作者信息
Mallat Ziad, Ait-Oufella Hafid, Tedgui Alain
机构信息
From the Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (Z.M.); and Institut National de la Santé et de la Recherche Médicale (Inserm) U970, Paris, France (Z.M., H.A.-O., A.T.).
出版信息
Circ Res. 2017 May 26;120(11):1718-1720. doi: 10.1161/CIRCRESAHA.116.310371.
Abstract
摘要
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本文引用的文献
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Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling.马凡综合征小鼠模型中的主动脉病变并非由转化生长因子β信号改变介导。
J Am Heart Assoc. 2017 Jan 24;6(1):e004968. doi: 10.1161/JAHA.116.004968.
2
Role of Microvascular Tone and Extracellular Matrix Contraction in the Regulation of Interstitial Fluid: Implications for Aortic Dissection.微血管张力和细胞外基质收缩在组织液调节中的作用：对主动脉夹层的影响
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1742-7. doi: 10.1161/ATVBAHA.116.307909. Epub 2016 Jul 21.
3
Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.LTBP-3对马凡综合征胸主动脉瘤贡献的遗传分析。
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14012-7. doi: 10.1073/pnas.1507652112. Epub 2015 Oct 22.
4
Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections.机械转导在血管生物学中的作用：聚焦胸主动脉瘤和夹层。
Circ Res. 2015 Apr 10;116(8):1448-61. doi: 10.1161/CIRCRESAHA.114.304936.
5
Muscle composition is regulated by a Lox-TGFβ feedback loop.肌肉组成由赖氨氧化酶-转化生长因子β反馈回路调控。
Development. 2015 Mar 1;142(5):983-93. doi: 10.1242/dev.113449.
6
Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.转化生长因子-β信号在小鼠主动脉瘤进展过程中的双相作用提示了马凡综合征的联合治疗方案。
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):911-7. doi: 10.1161/ATVBAHA.114.305150. Epub 2015 Jan 22.
7
Atenolol versus losartan in children and young adults with Marfan's syndrome.阿替洛尔与氯沙坦用于患有马凡氏综合征的儿童和年轻人的比较。
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Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.Tgfbr2 缺失导致出生后平滑肌功能障碍，破坏主动脉壁内稳态。
J Clin Invest. 2014 Feb;124(2):755-67. doi: 10.1172/JCI69942. Epub 2014 Jan 9.
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Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.血管紧张素 II 依赖性 TGF-β 信号通路参与了洛伊茨-迪茨综合征的血管发病机制。
J Clin Invest. 2014 Jan;124(1):448-60. doi: 10.1172/JCI69666. Epub 2013 Dec 20.
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