Zubov A N, Pisareva L N, Ivanova G I, Nosyreva E D
Tsitologiia. 1988 Dec;30(12):1487-91.
Blood plasma, serum and its fractions containing components of different molecular masses obtained by dialysis and gradual ultrafiltration were tested for their action on the sodium currents of voltage clamped internally perfused neuroblastoma cells. Blood plasma free of platelet factor 4, serum and its fractions containing components of molecular masses more than 50 kD produced an increase in sodium channel currents and shifts in activation and inactivation curves along the voltage axis towards more negative or positive potentials, respectively. Moreover, the serum deficient in components with the molecular masses less than 50 kD produced a more prominent effect on all the parameters tested. Thus, the low-molecular fractions were suggested to exert an inhibitory activity on the stimulatory effects produced by the high-molecular components of the serum.
通过透析和逐步超滤获得的含有不同分子量成分的血浆、血清及其组分，对电压钳制下内部灌注的神经母细胞瘤细胞的钠电流作用进行了测试。不含血小板因子4的血浆、血清及其含有分子量超过50 kD成分的组分，使钠通道电流增加，激活和失活曲线分别沿电压轴朝着更负或更正的电位移动。此外，缺乏分子量小于50 kD成分的血清对所有测试参数产生了更显著的影响。因此，提示低分子量组分对血清高分子量组分产生的刺激作用具有抑制活性。
