Veijalainen P M, Smeds E
Department of Virology, National Veterinary Institute, Helsinki, Finland.
Am J Vet Res. 1988 Nov;49(11):1941-4.
To study the pathogenicity of a newly isolated parvovirus of blue fox (Alopex lagopus), pregnant vixens and 43 kits of different ages were experimentally infected with the agent. The kits had no clinical signs of disease, even though most of them excreted virus in their feces, and they responded immunologically to viral exposure. Infection during pregnancy appeared to affect the fetuses. A group of 15 blue fox vixens inoculated with the virus produced a statistically smaller number of kits (78) than did 15 untreated controls (131). Vaccination with a homologous inactivated virus preparation appeared to afford protection against reproductive losses. After infection, 15 vaccinated vixens gave birth to 97 kits, compared with 54 kits born to a similar, non-vaccinated experimental group.
为研究新分离出的蓝狐细小病毒的致病性，对怀孕母狐和43只不同年龄的幼狐进行了该病原体的实验性感染。尽管大多数幼狐粪便中排出病毒，但它们没有疾病的临床症状，并且对病毒暴露产生了免疫反应。孕期感染似乎会影响胎儿。接种病毒的15只蓝狐母狐所产幼狐数量（78只）在统计学上明显少于15只未处理对照母狐所产幼狐数量（131只）。用同源灭活病毒制剂进行疫苗接种似乎可预防繁殖损失。感染后，15只接种疫苗的母狐产下97只幼狐，而类似的未接种疫苗实验组仅产下54只幼狐。
