依那普利的咪唑基衍生物作为潜在的血管紧张素转换酶抑制剂
Imidazolyl derivatives of enalapril as potential angiotensin converting enzyme inhibitors.
作者信息
Cecchi R, Ciabatti R, Favara D, Barone D, Baldoli E
出版信息
Farmaco Sci. 1985 Aug;40(8):541-54. doi: 10.1002/chin.198548187.
PMID:2995119
Abstract
The synthesis of a few derivatives of the angiotensin converting enzyme inhibitor enalapril is described. In these molecules the chelating carbethoxy group is substituted with an imidazolyl one. The compounds were tested both in vitro and in vivo. None of them showed in vivo activity but only a marginal in vitro inhibitory activity.
摘要
描述了血管紧张素转换酶抑制剂依那普利的几种衍生物的合成。在这些分子中，螯合乙氧羰基被咪唑基取代。这些化合物在体外和体内都进行了测试。它们在体内均无活性，但仅具有微弱的体外抑制活性。
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