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嘌呤核苷对肉鸡生长性能、肠道形态、消化酶、血清指标及免疫反应的影响。

Effect of purine nucleosides on growth performance, gut morphology, digestive enzymes, serum profile and immune response in broiler chickens.

作者信息

Daneshmand A, Kermanshahi Hassan, Danesh Mesgaran M, King A J, Ibrahim S A

机构信息

a Department of Animal Science, Faculty of Agriculture , Ferdowsi University of Mashhad , Mashhad , Iran.

b Department of Animal Science , University of California , Davis , CA , USA.

出版信息

Br Poult Sci. 2017 Oct;58(5):536-543. doi: 10.1080/00071668.2017.1335859. Epub 2017 Jun 12.

Abstract
  1. This study was conducted to evaluate the effects of purine nucleosides on performance, gut morphology, intestinal enzymes and immunity functions in broiler chickens from 0 to 21 d of age. 2. A total of 360 1-d-old male chickens (Cobb 500) were randomly assigned to 4 treatments with 6 replications. Experimental diets consisted of a control without any additives and diets containing 0.1% pure adenosine, 0.1% pure guanosine and 0.1% equal aliquots of pure adenosine and guanosine. Two birds per cage (12 birds per treatment) were killed on d 11 and 21 in order to obtain serum samples for lipid profile, jejunal samples for morphology and mucosal immunity, digestive enzymes for epithelial maturation, and bursa and spleen samples for relative weight of immune organs to live body weight. 3. Birds receiving adenosine in their diets showed a significant increase in body weight and average daily gain and a significantly lower feed conversion ratio compared to the control birds. Villus height and width in jejunal samples also increased significantly in birds supplemented with adenosine. Although maltase was not affected by the experimental diets, adenosine increased alkaline phosphatase and aminopeptidase. Adenosine and its combination with guanosine boosted mucosal immunity as a result of increased IgA production. While there was no significant difference among treatments regarding the relative weight of the spleen, adenosine increased the relative weight of the bursa of Fabricius. Present results also showed that adding guanosine to broiler diets had no significant effects on growth, gut morphology, enzymes activity and immunological indices. 4. In conclusion, the improvement in growth performance, gut morphology and immunity in birds receiving adenosine demonstrated that pure adenosine could be a beneficial feed additive for the poultry industry, while guanosine showed no significant improvement.
摘要
  1. 本研究旨在评估嘌呤核苷对0至21日龄肉鸡生产性能、肠道形态、肠道酶及免疫功能的影响。2. 总共360只1日龄雄性肉鸡(科宝500)被随机分为4个处理组,每组6个重复。实验日粮包括不含任何添加剂的对照组以及分别含有0.1%纯腺苷、0.1%纯鸟苷和0.1%等量纯腺苷与鸟苷的日粮。为获取用于血脂分析的血清样本、用于形态学和黏膜免疫分析的空肠样本、用于上皮成熟分析的消化酶样本以及用于免疫器官与活体体重相对重量分析的法氏囊和脾脏样本,在第11天和第21天每组笼舍处死2只鸡(每个处理组12只鸡)。3. 与对照组相比,日粮中添加腺苷的鸡体重和平均日增重显著增加,饲料转化率显著降低。补充腺苷的鸡空肠样本中的绒毛高度和宽度也显著增加。虽然麦芽糖酶不受实验日粮影响,但腺苷可提高碱性磷酸酶和氨肽酶活性。腺苷及其与鸟苷的组合因IgA产量增加而增强了黏膜免疫。虽然各处理组脾脏相对重量无显著差异,但腺苷增加了法氏囊的相对重量。目前的结果还表明,在肉鸡日粮中添加鸟苷对生长性能、肠道形态、酶活性和免疫指标无显著影响。4. 总之,日粮中添加腺苷的鸡生长性能、肠道形态和免疫力的改善表明,纯腺苷可能是家禽业有益的饲料添加剂,而鸟苷未显示出显著改善效果。

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