Hou Longlei, Yuan Yuejie, Tong Xiaofeng
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, 200237, Shanghai, China.
Org Biomol Chem. 2017 Jun 7;15(22):4803-4806. doi: 10.1039/c7ob00762k.
A Pd(0)/(S)-p-MeO-BnPHOX catalytic system has been established for the asymmetric reductive Heck reaction of (Z)-1-iodo-1,6-dienes, which affords quaternary tetrahydropyridines with good to excellent enantioselectivities. This reaction tolerates a wide range of substituted alkene moieties, including 1,1-disubstituted, 1,1,2-trisubstituted as well as 1,2-disubstituted alkenes.
已建立了一种用于（Z）-1-碘-1,6-二烯不对称还原Heck反应的Pd(0)/(S)-对甲氧基苄基膦氧化物（(S)-p-MeO-BnPHOX）催化体系，该反应能以良好至优异的对映选择性得到季碳四氢吡啶。该反应能耐受多种取代的烯烃部分，包括1,1-二取代、1,1,2-三取代以及1,2-二取代的烯烃。
