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同种异体软骨基质关节镜下治疗距骨骨软骨损伤

Arthroscopic Treatment of Osteochondral Lesions of the Talus With Allograft Cartilage Matrix.

作者信息

Ahmad Jamal, Maltenfort Mitchell

机构信息

1 Orthopaedic Foot and Ankle Surgery, NorthShore Orthopaedic Institute, NorthShore University Health System, Lincolnshire, IL, USA.

2 Biostatistician, Children's Hospital of Philadelphia, Department of Biomedical Health Informatics, Philadelphia, PA, USA.

出版信息

Foot Ankle Int. 2017 Aug;38(8):855-862. doi: 10.1177/1071100717709571. Epub 2017 May 26.

Abstract

BACKGROUND

This prospective study evaluated the intermediate-term outcomes of operatively treating primary osteochondral lesions of the talus (OLT) of 1.5 cm or smaller with arthroscopic excision, microfracture, and allograft cartilage extracellular matrix (ECM).

METHODS

Between 2012 and 2015, 30 consecutive patients received allograft cartilage ECM at their microfractured OLT of 1.5 cm or smaller after failing nonoperative treatment. Preoperative and postoperative function and pain were graded using the Foot and Ankle Ability Measure (FAAM) and a visual analog scale (VAS), respectively. Postoperative imaging was assessed for osteochondral healing and degenerative changes. This included computed tomography (CT) at 6 months from surgery. Data regarding postoperative complications were recorded. All 30 patients that received allograft cartilage ECM for their OLT were evaluated for final follow-up at a mean of 20.2 months.

RESULTS

Mean FAAM increased from 51.4 preoperatively to 89.3 of 100 at final follow-up. Mean VAS decreased from 8.1 preoperatively to 1.7 of 10 at final follow-up. These differences between preoperative and postoperative function and pain were statistically significant ( P < .05). At 6 months from surgery, 2 patients (6.7%) received CT scans that revealed incomplete chondral formation at their OLT. At 19 months after surgery, a separate patient (3.3%) developed ankle arthritic changes.

CONCLUSION

Treating OLTs with allograft cartilage ECM has not been previously reported. Using allograft cartilage ECM resulted in a high rate of improvement in ankle function and pain in patients with OLTs. These findings are important as allograft cartilage ECM could be of significant benefit for patients with OLTs.

LEVEL OF EVIDENCE

Level III, prospective comparative series.

摘要

背景

本前瞻性研究评估了关节镜下切除、微骨折和同种异体软骨细胞外基质(ECM)治疗直径1.5厘米及以下距骨原发性骨软骨损伤(OLT)的中期疗效。

方法

2012年至2015年期间,30例连续患者在非手术治疗失败后,于直径1.5厘米及以下的微骨折OLT处接受了同种异体软骨ECM治疗。术前和术后功能及疼痛分别采用足踝能力测量量表(FAAM)和视觉模拟量表(VAS)进行评分。术后通过影像学检查评估骨软骨愈合及退变情况。这包括术后6个月的计算机断层扫描(CT)。记录术后并发症相关数据。对所有30例接受同种异体软骨ECM治疗OLT的患者进行了平均20.2个月的最终随访评估。

结果

最终随访时,FAAM平均得分从术前的51.4提高到了100分中的89.3分。VAS平均得分从术前的8.1分降至最终随访时的10分中的1.7分。术前和术后功能及疼痛的这些差异具有统计学意义(P <.05)。术后6个月,2例患者(6.7%)接受CT扫描显示OLT处软骨形成不完全。术后19个月,另1例患者(3.3%)出现踝关节关节炎改变。

结论

此前尚未有使用同种异体软骨ECM治疗OLT的报道。使用同种异体软骨ECM可使OLT患者的踝关节功能和疼痛得到显著改善。这些发现很重要,因为同种异体软骨ECM可能对OLT患者有显著益处。

证据水平

三级,前瞻性比较系列研究。

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