Adams Samuel B, Dekker Travis J, Schiff Adam P, Gross Christopher P, Nunley James A, Easley Mark E
1 Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, USA.
Foot Ankle Int. 2018 Jan;39(1):28-34. doi: 10.1177/1071100717732342. Epub 2017 Oct 3.
Structural or bulk osteochondral allograft transplantation for shoulder talar osteochondral lesions as a salvage procedure has demonstrated efficacy in several retrospective reviews. The purpose of this study was to evaluate prospectively patients who received fresh structural allograft transplantation to the talus.
Prospective evaluation of a consecutive series of patients who underwent fresh structural allograft transplantation for an osteochondral lesion of the talus (OLT) was performed. Preoperative magnetic resonance imaging (MRI) and/or computed tomography (CT) and plain radiographs were obtained on all patients. The following patient-reported outcomes questionnaires were administered preoperatively and yearly after surgery: 100-mm visual analog scale (VAS) pain scale, American Orthopaedic Foot & Ankle Society (AOFAS) Ankle-Hindfoot Scale, Short Form 36 (SF-36), and the Short Musculoskeletal Functional Assessment (SMFA). Preoperative and postoperative radiographs were assessed for allograft incorporation and subsequent arthritis. Fourteen patients with an average age of 40 years (range, 18-69) and a mean follow-up of 55 months (range, 24-97) underwent structural fresh osteochondral allograft transplantation to the talar shoulder.
The average size of the OLT was 2269 mm (range, 813-8366) based on CT imaging and 5797 mm (range, 1136-12 489) based on MRI imaging. There was significant ( P < .05) improvement in the VAS pain, AOFAS scale, SF-36, and SMFA scores. Five (36%) of the patients required additional surgery for pain and stiffness. Two patients had cartilage delamination and were considered treatment failures. Therefore, the success rate was 86% (12/14).
Significant improvement in pain and function was achieved with structural allograft transplantation for large OLTs at midterm follow-up. This was a safe and effective treatment option in this small series for large OLTs.
Level IV, prospective case series.
在一些回顾性研究中,结构性或大块骨软骨异体移植用于治疗距骨骨软骨损伤作为一种挽救性手术已显示出疗效。本研究的目的是对接受新鲜距骨结构性异体移植的患者进行前瞻性评估。
对一系列连续接受新鲜距骨结构性异体移植治疗距骨骨软骨损伤(OLT)的患者进行前瞻性评估。所有患者均进行了术前磁共振成像(MRI)和/或计算机断层扫描(CT)以及X线平片检查。术前及术后每年对患者进行以下报告结局问卷评估:100毫米视觉模拟量表(VAS)疼痛评分、美国矫形足踝协会(AOFAS)踝-后足评分、简明健康状况调查量表(SF-36)以及简短肌肉骨骼功能评估量表(SMFA)。对术前和术后的X线片进行评估,以观察异体骨融合情况及随后的关节炎情况。14例平均年龄40岁(范围18 - 69岁)、平均随访55个月(范围24 - 97个月)的患者接受了距骨肩部新鲜结构性骨软骨异体移植。
基于CT成像,OLT的平均大小为2269平方毫米(范围813 - 8366平方毫米),基于MRI成像为5797平方毫米(范围1136 - 12489平方毫米)。VAS疼痛评分、AOFAS评分、SF-36评分和SMFA评分均有显著改善(P < 0.05)。5例(36%)患者因疼痛和僵硬需要再次手术。2例患者出现软骨分层,被视为治疗失败。因此,成功率为86%(12/14)。
在中期随访中,结构性异体移植治疗大型OLT可显著改善疼痛和功能。在这个小型系列研究中,这是一种治疗大型OLT安全有效的选择。
IV级,前瞻性病例系列。