锰（I）催化的吡啶酮和吲哚的 C-H 3,3-二氟烯丙基化反应。
Manganese(I)-Catalyzed C-H 3,3-Difluoroallylation of Pyridones and Indoles.
机构信息
CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences , Shanghai 201203, China.
State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China.
出版信息
Org Lett. 2017 Jun 16;19(12):3159-3162. doi: 10.1021/acs.orglett.7b01282. Epub 2017 May 26.
A novel and efficient C-H activation approach for the direct 3,3-difluoroallylation of 2-pyridones and indoles is herein reported using a manganese(I) complex as the catalyst. A broad range of substrates with diverse functional groups were tolerated. Moreover, late-stage C-H functionalization of bioactive molecules was achieved in good yield.
本文报道了一种新颖、高效的 C-H 活化方法，通过锰（I）配合物作为催化剂，实现了 2-吡啶酮和吲哚的直接 3,3-二氟烯丙基化反应。该方法具有广泛的底物适用性，能够容忍多种不同官能团的底物。此外，还实现了生物活性分子的后期 C-H 官能团化，产率良好。
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