a Frontier Research Institute for Interdisciplinary Sciences, Tohoku University , Sendai , Japan.
b Graduate School of Life Sciences, Tohoku University , Sendai , Japan.
Autophagy. 2017 Jul 3;13(7):1239-1240. doi: 10.1080/15548627.2017.1310360. Epub 2017 May 26.
In yeast and mammals, selective vacuolar delivery and degradation of whole mitochondria, or mitophagy, represents an important quality control system and is achieved by a cargo recognition mechanism enabling selective elimination of dysfunctional mitochondria. As photosynthetic organelles that need light for energy production, plant chloroplasts accumulate sunlight-induced damage. Plants have evolved multiple mechanisms to avoid, relieve, or repair chloroplast photodamage. Our recent study showed that vacuolar degradation of entire chloroplasts, termed chlorophagy, is induced to degrade chloroplasts that are collapsed due to photodamage. Our results underscore the involvement of autophagy in the quality control of endosymbiotic, energy-converting organelles in eukaryotes.
在酵母和哺乳动物中，通过一种货物识别机制实现整个线粒体（或自噬）的选择性液泡递送到降解，这代表了一种重要的质量控制系统，可实现对功能失调的线粒体的选择性消除。作为需要光来产生能量的光合作用细胞器，植物叶绿体积累了光诱导的损伤。植物已经进化出多种机制来避免、缓解或修复叶绿体光损伤。我们最近的研究表明，整个叶绿体的液泡降解，称为自噬，被诱导来降解由于光损伤而崩溃的叶绿体。我们的研究结果强调了自噬在真核生物中内共生、能量转换细胞器的质量控制中的作用。
