Lopez-Bujanda Zoila, Drake Charles G
Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
J Leukoc Biol. 2017 Aug;102(2):393-406. doi: 10.1189/jlb.5VMR1116-491RR. Epub 2017 May 26.
Prostate cancer is the second most common cause of cancer mortality in men in the United States. As is the case for other tumor types, accumulating evidence suggests an important role for myeloid-derived cells in the promotion and progression of prostate cancer. Here, we briefly describe myeloid-derived cells that interact with tumor cells and what is known about their immune suppressive function. We next discuss new evidence for tumor cell-mediated myeloid infiltration via the PI3K/PTEN/AKT signaling pathway and an alternative mechanism for immune evasion that may be regulated by an endoplasmic reticulum stress response. Finally, we discuss several interventions that target myeloid-derived cells to treat prostate cancer.
前列腺癌是美国男性癌症死亡的第二大常见原因。与其他肿瘤类型一样，越来越多的证据表明髓系来源的细胞在前列腺癌的发生和发展中起重要作用。在此，我们简要描述与肿瘤细胞相互作用的髓系来源的细胞，以及关于它们免疫抑制功能的已知情况。接下来，我们讨论肿瘤细胞通过PI3K/PTEN/AKT信号通路介导髓系浸润的新证据，以及一种可能由内质网应激反应调节的免疫逃逸替代机制。最后，我们讨论几种针对髓系来源的细胞来治疗前列腺癌的干预措施。
