癌症与其细胞微环境之间的相互作用——在癌症进展中的作用
Cross-Talk Between Cancer and Its Cellular Environment-A Role in Cancer Progression.
作者信息
Turlej Eliza, Domaradzka Aleksandra, Radzka Justyna, Drulis-Fajdasz Dominika, Kulbacka Julita, Gizak Agnieszka
机构信息
Departament of Molecular Physiology and Neurobiology, University of Wrocław, ul. Sienkiewicza 21, 50-335 Wrocław, Poland.
Departament of Molecular and Cellular Biology, Faculty of Pharmacy, Wrocław Medical University, Borowska 211A, 50-556 Wrocław, Poland.
出版信息
Cells. 2025 Mar 10;14(6):403. doi: 10.3390/cells14060403.
The tumor microenvironment is a dynamic and complex three-dimensional network comprising the extracellular matrix and diverse non-cancerous cells, including fibroblasts, adipocytes, endothelial cells and various immune cells (lymphocytes T and B, NK cells, dendritic cells, monocytes/macrophages, myeloid-derived suppressor cells, and innate lymphoid cells). A constantly and rapidly growing number of studies highlight the critical role of these cells in shaping cancer survival, metastatic potential and therapy resistance. This review provides a synthesis of current knowledge on the modulating role of the cellular microenvironment in cancer progression and response to treatment.
肿瘤微环境是一个动态且复杂的三维网络，由细胞外基质和多种非癌细胞组成，包括成纤维细胞、脂肪细胞、内皮细胞以及各种免疫细胞（T和B淋巴细胞、自然杀伤细胞、树突状细胞、单核细胞/巨噬细胞、髓源性抑制细胞和先天性淋巴细胞）。越来越多的研究不断迅速凸显出这些细胞在塑造癌症生存、转移潜能和治疗抗性方面的关键作用。本综述对细胞微环境在癌症进展和治疗反应中的调节作用的现有知识进行了综合阐述。
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