Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, AZ, USA.
Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
J Alzheimers Dis. 2017;58(4):1273-1281. doi: 10.3233/JAD-170041.
Altered cortical thickness has been observed in aging and various neurodegenerative disorders. Furthermore, reduced hippocampal volume has been reported in late-life depression. Even mild depressive symptoms are common in the elderly. However, little is known about the structural MRI measures of depressive symptoms in normal cognitive aging. Thus we sought to examine the association between depressive symptoms with cortical thickness and hippocampal volume as measured by brain MRI among community-dwelling participants. We conducted a cross-sectional study derived from the ongoing population-based Mayo Clinic Study of Aging, involving cognitively normal participants (N = 1,507) aged≥70 years. We observed that depressive symptoms were associated with lower global cortical thickness and lower thickness in specific prefrontal and temporal cortical regions, labeled by FreeSurfer software, version 5.3. As expected, the strength of correlation was very small, given that participants were community-dwelling with only mild depressive symptoms. We did not observe associations between hippocampal volume and depressive symptoms. These findings may provide insight into the structural correlates of mild depressive symptoms in elderly participants.
在衰老和各种神经退行性疾病中，观察到皮质厚度的改变。此外，在迟发性抑郁症中，海马体积减少。即使是轻度抑郁症状在老年人中也很常见。然而，对于正常认知衰老中抑郁症状的结构 MRI 测量，我们知之甚少。因此，我们试图研究大脑 MRI 测量的皮质厚度和海马体积与社区居住参与者抑郁症状之间的关联。我们进行了一项横断面研究，该研究源自正在进行的基于人群的梅奥诊所衰老研究，涉及认知正常的参与者（N=1507），年龄≥70 岁。我们观察到，抑郁症状与全球皮质厚度降低和特定额皮质和颞皮质区域的厚度降低有关，这些区域由 FreeSurfer 软件，版本 5.3 标记。正如预期的那样，由于参与者是社区居住，只有轻度抑郁症状，所以相关性的强度非常小。我们没有观察到海马体积和抑郁症状之间的关联。这些发现可能为理解老年参与者轻度抑郁症状的结构相关性提供了线索。
