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常染色体显性阿尔茨海默病患者的抑郁症状与海马体积。

Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease.

机构信息

Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia.

出版信息

Alzheimers Dement. 2024 Feb;20(2):986-994. doi: 10.1002/alz.13501. Epub 2023 Oct 14.

DOI:10.1002/alz.13501
PMID:37837524
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10916972/
Abstract

INTRODUCTION

Depressive symptoms are among early behavioral changes in Alzheimer's disease (AD); however, the relationship between neurodegeneration and depressive symptoms remains inconclusive. To better understand this relationship in preclinical AD, we examined hippocampal volume and depressive symptoms in cognitively unimpaired carriers of the presenilin-1 (PSEN1) E280A mutation for autosomal dominant AD.

METHODS

A total of 27 PSEN1 mutation carriers and 26 non-carrier family members were included. Linear regression was used to test the relationship between hippocampal volume and 15-item Geriatric Depression Scale.

RESULTS

Carriers and non-carriers did not differ in depressive symptoms or hippocampal volume. Within carriers, lower hippocampal volume was associated with greater depressive symptoms, which remained significant after adjusting for age and cognition. This relationship was not significant in non-carriers.

DISCUSSION

Hippocampal neurodegeneration may underlie depressive symptoms in preclinical autosomal dominant AD. These findings provide support for the utility of targeting depressive symptoms in AD prevention.

HIGHLIGHTS

We compared unimpaired autosomal dominant Alzheimer's disease (AD) mutation carriers and non-carriers. Carriers and non-carriers did not differ in severity of depressive symptoms. In carriers, hippocampal volume was inversely associated with depressive symptoms. Depressive symptoms may be a useful target in AD prevention.

摘要

简介

抑郁症状是阿尔茨海默病（AD）早期行为变化之一；然而，神经退行性变与抑郁症状之间的关系仍不清楚。为了在临床前 AD 中更好地理解这种关系，我们检查了认知无障碍携带早老素-1（PSEN1） E280A 突变的常染色体显性 AD 患者的海马体积和抑郁症状。

方法

共纳入 27 名 PSEN1 突变携带者和 26 名非携带者家族成员。线性回归用于测试海马体积与 15 项老年抑郁量表之间的关系。

结果

携带者和非携带者在抑郁症状或海马体积上没有差异。在携带者中，较低的海马体积与更严重的抑郁症状相关，在调整年龄和认知后仍然显著。在非携带者中，这种关系并不显著。

讨论

海马神经退行性变可能是临床前常染色体显性 AD 中抑郁症状的基础。这些发现为在 AD 预防中针对抑郁症状提供了支持。

要点

我们比较了无症状的常染色体显性 AD（AD）突变携带者和非携带者。携带者和非携带者在抑郁症状严重程度上没有差异。在携带者中，海马体积与抑郁症状呈负相关。抑郁症状可能是 AD 预防的一个有用目标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e72/10916972/dce18fa5ccce/ALZ-20-986-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e72/10916972/d851b8de0c26/ALZ-20-986-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e72/10916972/dce18fa5ccce/ALZ-20-986-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e72/10916972/d851b8de0c26/ALZ-20-986-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e72/10916972/dce18fa5ccce/ALZ-20-986-g002.jpg

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