Unité 1237 PhIND "Physiopathology and Imaging of Neurological Disorders", Institut National de la Santé et de la Recherche Médicale, Blood and Brain @ Caen-Normandie, GIP Cyceron, Normandie Université, Université de Caen, Caen, France.
Unité 1077 NIMH "Neuropsychologie et Imagerie de la Mémoire Humaine," Institut National de la Santé et de la Recherche Médicale, Normandie Université, Université de Caen, PSL Université, EPHE, CHU de Caen-Normandie, GIP Cyceron, Caen, France.
Mol Psychiatry. 2022 Dec;27(12):5086-5095. doi: 10.1038/s41380-022-01772-8. Epub 2022 Oct 18.
Subclinical depressive symptoms are associated with increased risk of Alzheimer's disease (AD), but the brain mechanisms underlying this relationship are still unclear. We aimed to provide a comprehensive overview of the brain substrates of subclinical depressive symptoms in cognitively unimpaired older adults using complementary multimodal neuroimaging data. We included cognitively unimpaired older adults from the baseline data of the primary cohort Age-Well (n = 135), and from the replication cohort ADNI (n = 252). In both cohorts, subclinical depressive symptoms were assessed using the 15-item version of the Geriatric Depression Scale; based on this scale, participants were classified as having depressive symptoms (>0) or not (0). Voxel-wise between-group comparisons were performed to highlight differences in gray matter volume, glucose metabolism and amyloid deposition; as well as white matter integrity (only available in Age-Well). Age-Well participants with subclinical depressive symptoms had lower gray matter volume in the hippocampus and lower white matter integrity in the fornix and the posterior parts of the cingulum and corpus callosum, compared to participants without symptoms. Hippocampal atrophy was recovered in ADNI, where participants with subclinical depressive symptoms also showed glucose hypometabolism in the hippocampus, amygdala, precuneus/posterior cingulate cortex, medial and dorsolateral prefrontal cortex, insula, and temporoparietal cortex. Subclinical depressive symptoms were not associated with brain amyloid deposition in either cohort. Subclinical depressive symptoms in ageing are linked with neurodegeneration biomarkers in the frontolimbic network including brain areas particularly sensitive to AD. The relationship between depressive symptoms and AD may be partly underpinned by neurodegeneration in common brain regions.
亚临床抑郁症状与阿尔茨海默病（AD）风险增加相关，但两者之间的大脑机制尚不清楚。我们旨在使用互补的多模态神经影像学数据，为认知正常的老年人亚临床抑郁症状的大脑基质提供全面概述。我们纳入了主要队列 Age-Well 的基线数据中的认知正常的老年人（n=135）和 ADNI 的复制队列中的老年人（n=252）。在这两个队列中，使用 15 项老年抑郁量表评估亚临床抑郁症状；根据该量表，参与者被分为有抑郁症状（>0）或没有抑郁症状（0）。进行了基于体素的组间比较，以突出灰质体积、葡萄糖代谢和淀粉样蛋白沉积以及白质完整性的差异（仅在 Age-Well 中可用）。与无症状的参与者相比，有亚临床抑郁症状的 Age-Well 参与者的海马体灰质体积较低，穹窿和扣带回后段以及胼胝体体部的白质完整性较低。在 ADNI 中，亚临床抑郁症状的参与者的海马体也表现出葡萄糖代谢低下，而海马体、杏仁核、楔前叶/后扣带皮质、内侧和背外侧前额叶皮质、岛叶和颞顶叶皮质等区域也出现了萎缩。在两个队列中，亚临床抑郁症状与脑淀粉样蛋白沉积均无关。衰老中的亚临床抑郁症状与额-边缘网络中的神经退行性变生物标志物有关，包括对 AD 特别敏感的大脑区域。抑郁症状与 AD 之间的关系可能部分由常见脑区的神经退行性变所支撑。
