Independent Scientist, Bethesda, Md.
Sungshin Women's University College of Nursing, Seoul, Korea.
J Allergy Clin Immunol Pract. 2017 Nov-Dec;5(6):1679-1690. doi: 10.1016/j.jaip.2017.03.036. Epub 2017 May 24.
Asthma is associated with adverse pregnancy outcomes. At the same time there is a worldwide increase in asthma and hay fever.
This study addresses whether asthma and/or hay fever adversely influence pregnancy outcomes.
Data from the 1995 National Survey of Family Growth that include a history of diagnosed asthma, hay fever, and adverse pregnancy outcomes in 10,847 women representative of the US population aged 15 to 44 years were analyzed.
Women with the allergic phenotypes asthma and hay fever and hay fever only had no significant increase in adverse pregnancy outcomes (spontaneous pregnancy loss, preterm birth, infant low birth weight), whereas women with the nonatopic phenotype asthma only (without hay fever) did. The study did not evaluate endotypes.
This study provides new data that the allergic phenotypes, asthma and hay fever and hay fever only, are compatible with healthy pregnancy, whereas the nonatopic asthma phenotype, asthma only, adversely impacts pregnancy.
哮喘与不良妊娠结局相关。与此同时，哮喘和花粉热在全球范围内的发病率都有所上升。
本研究旨在探讨哮喘和/或花粉热是否会对妊娠结局产生不利影响。
对代表美国 15 至 44 岁人群的 10847 名女性的 1995 年全国家庭增长调查数据进行了分析，这些数据包括既往诊断的哮喘、花粉热以及不良妊娠结局的病史。
具有过敏表型哮喘和花粉热以及仅有花粉热的女性不良妊娠结局（自然流产、早产、婴儿低出生体重）没有显著增加，而仅有非特应性表型哮喘（无花粉热）的女性则有。本研究未评估内型。
本研究提供了新的数据，表明过敏表型哮喘和花粉热以及仅有花粉热与健康妊娠相容，而非特应性哮喘表型哮喘仅会对妊娠产生不利影响。
