David Geffen School of Medicine, Los Angeles, CA, USA.
Division of Dermatology, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA, USA.
Arch Dermatol Res. 2024 Sep 14;316(9):620. doi: 10.1007/s00403-024-03373-7.
Asthma is a respiratory disorder caused by airway inflammation which may worsen after allergen exposure. Recent cohort studies demonstrate a positive association between skin cancer and asthma or hay fever (allergy to outdoor allergens such as pollen). Nationally-representative data for adults in the United States remains limited. We aimed to characterize skin cancer prevalence among individuals in the United States who have asthma or hay fever. To achieve this aim, we extracted nationwide cross-sectional data from 16,277 adult participants (total survey-weighted sample = 174,765,931) of the Third National Health and Nutrition Examination Survey from 1988 to 1994. This study uses survey-weighted regression to compare the nationwide prevalence of skin cancer among participants with or without a history of asthma or hay fever. Sensitivity analysis examined the influence of sex, 25-hydroxyvitamin D, chronic bronchitis or emphysema, geographical region, urban proximity, and oral glucocorticoid use. Of the included participants, the age-adjusted prevalence of skin cancer was 7.2%, similar to national estimates. Skin cancer prevalence was higher among participants who had asthma with hay fever (adjusted prevalence ratio, 1.79; 95% confidence interval, 1.16, 2.76), but not among participants with asthma only or hay fever only. Similarly, skin cancer prevalence was higher for those with asthma and positive pollen allergen skin prick testing (SPT), but not for those with hay fever and positive pollen SPT. No association was noted between skin cancer and wheezing triggered by pollen. Hay fever or immunoglobulin-E sensitization to pollen may increase skin cancer prevalence among individuals with a history of asthma.
哮喘是一种由气道炎症引起的呼吸系统疾病，过敏原暴露后可能会加重。最近的队列研究表明，皮肤癌与哮喘或花粉热（对花粉等户外过敏原的过敏）之间存在正相关关系。美国成年人的全国代表性数据仍然有限。我们旨在描述美国患有哮喘或花粉热的个体中皮肤癌的患病率。为了实现这一目标，我们从 1988 年至 1994 年进行的第三次国家健康和营养检查调查中提取了 16277 名成年参与者（总调查加权样本量为 174765931）的全国性横断面数据。本研究使用调查加权回归来比较有或没有哮喘或花粉热病史的参与者中皮肤癌的全国患病率。敏感性分析检查了性别、25-羟维生素 D、慢性支气管炎或肺气肿、地理区域、城市接近度和口服糖皮质激素使用的影响。在纳入的参与者中，皮肤癌的年龄调整患病率为 7.2%，与全国估计值相似。患有哮喘和花粉热的参与者的皮肤癌患病率较高（调整后的患病率比，1.79；95%置信区间，1.16，2.76），但仅患有哮喘或花粉热的参与者则不然。同样，患有哮喘和阳性花粉过敏原皮肤点刺试验（SPT）的参与者的皮肤癌患病率较高，但花粉 SPT 阳性的花粉热患者则不然。花粉诱发的喘息与皮肤癌之间没有关联。花粉热或对花粉的免疫球蛋白 E 致敏可能会增加有哮喘病史的个体的皮肤癌患病率。
