动脉自旋标记磁共振成像（MRI）与氟代脱氧葡萄糖正电子发射断层显像（FDG PET-CT）在疑似早期痴呆中的定性一致性及诊断性能：疑似痴呆中动脉自旋标记MRI与FDG PET-CT的比较
Qualitative agreement and diagnostic performance of arterial spin labelling MRI and FDG PET-CT in suspected early-stage dementia: Comparison of arterial spin labelling MRI and FDG PET-CT in suspected dementia.
作者信息
Weyts Kathleen, Vernooij Meike, Steketee Rebecca, Valkema Roelf, Smits Marion
机构信息
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
出版信息
Clin Imaging. 2017 Sep-Oct;45:1-7. doi: 10.1016/j.clinimag.2017.05.008. Epub 2017 May 19.
18FDG PET-CT is useful for early and differential diagnosis of dementia. ASL-MRI seems an attractive alternative. Visual agreement was calculated in 21 brain regions bilaterally in 9/11 patients with suspected early-stage dementia, excluding 2 patients due to ASL-MRI motion artefacts. Overall gross agreement was almost perfect and identical between and within modalities (κ=0.85-0.86, p<0.05). Intermodality regional agreement was variable, moderate (κ=0,56 in posterior cingulate) to perfect (including in precuneus), not different from intramodality agreement. Diagnostic accuracy was 5/9 (56%) for ASL-MRI and 7/9 (78%) for FDG PETCT. (p=0.31). Clinical experience and optimisation may further improve ASL-MRI's performance.
18氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（18FDG PET-CT）对痴呆的早期诊断和鉴别诊断很有用。动脉自旋标记磁共振成像（ASL-MRI）似乎是一种有吸引力的替代方法。对9/11例疑似早期痴呆患者的双侧21个脑区计算视觉一致性，排除2例因ASL-MRI运动伪影的患者。总体总体一致性在不同模态之间和模态内部几乎完美且相同（κ=0.85-0.86，p<0.05）。模态间区域一致性各不相同，从中度（后扣带回κ=0.56）到完美（包括楔前叶），与模态内一致性无差异。ASL-MRI的诊断准确率为5/9（56%），18FDG PET-CT的诊断准确率为7/9（78%）。（p=0.31）。临床经验和优化可能会进一步提高ASL-MRI的性能。
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